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Hatun, Şükrü

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Şükrü

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    Familial hypomagnesemia with hypercalciuria and nephrocalcinosis due to CLDN16 gene mutations: novel findings in two cases with diverse clinical features
    (Springer, 2022) Eltan, Mehmet; Abalı, Zehra Yavaş; Türkyılmaz, Ayberk; Gökçe, İbrahim; Abalı, Saygın; Alavanda, Ceren; Arman, Ahmet; Kırkgoz, Tarık; Güran, Tülay; Bereket, Abdullah; Turan, Serap; N/A; Hatun, Şükrü; Faculty Member; School of Medicine; 153504
    Biallelic loss of function mutations in the CLDN16 gene cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and chronic kidney disease. Here we report two cases of FHHNC with diverse clinical presentations and hypercalcemia in one as a novel finding. Pt#1 initially presented with urinary tract infection and failure to thrive at 5.5 months of age to another center. Bilateral nephrocalcinosis, hypercalcemia (Ca: 12.2 mg/dl), elevated parathyroid hormone (PTH) level, and hypercalciuria were detected. Persistently elevated PTH with high/normal Ca levels led to subtotal-parathyroidectomy at the age of 2.5. However, PTH levels remained elevated with progressive deterioration in renal function. At 9-year-old, she was referred to us for evaluation of hyperparathyroidism and, hypomagnesemia together with hypercalciuria, elevated PTH with normal Ca levels, and medullary nephrocalcinosis were detected. Compound heterozygosity of CLDN16 variants (c.715G>A, p.G239R; and novel c.360C>A, p.C120*) confirmed the diagnosis. Pt#2 was a 10-month-old boy, admitted with irritability and urinary crystals. Hypocalcemia, hypophosphatemia, elevated PTH and ALP, low 25(OH)D levels, and radiographic findings of rickets were detected. However, additional findings of hypercalciuria and bilateral nephrocalcinosis were inconsistent with the nutritional rickets. Low/normal serum Mg levels suggested the diagnosis of FHHNC which was confirmed genetically as a homozygous missense (c.602G > A; p.G201E) variant in CLDN16. Yet, hypocalcemia and hypomagnesemia persisted in spite of treatment. In conclusion, FHHNC may present with diverse clinical features with mild hypomagnesemia leading to secondary hyperparathyroidism with changing Ca levels from low to high. Early and accurate clinical and molecular genetic diagnosis is important for proper management.
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    I'm not alone-my take-away message from the my friend diabetes camp
    (Springernature, 2020) N/A; N/A; Yeşiltepe Mutlu, Rahime Gül; Gökçe, Tuğba; Can, Ecem; Muradoğlu, Serra Küpçüoğlu; Hatun, Şükrü; Faculty Member; Doctor; Nurse; Doctor; Faculty Member; School of Medicine; N/A; N/A; N/A; School of Medicine; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; 153511; N/A; N/A; N/A; 153504
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    A rare cause of chronic hyponatremia in an infant: aldosterone synthase type-2 deficiency
    (Springer, 2018) Güran, Tülay; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Börklü Yücel, Esra; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; N/A; 221274; N/A; 153504; 7945; 198907
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    A short-term evaluation of children with diabetes using medtronic 780g system- a single center experience from Turkey
    (Mary Ann Liebert, Inc, 2022) N/A; N/A; Yeşiltepe Mutlu, Rahime Gül; Eviz, Elif; Can, Ecem; Gökçe, Tuğba; Muradoğlu, Serra Küpçüoğlu; Hatun, Şükrü; Faculty Member; Researcher; Nurse; Doctor; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; 153511; 327618; N/A; N/A; N/A; 153504
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    The attitudes, experiences, and self-competencies of pediatric endocrinology fellows and attending physicians regarding diabetes technology: the Turkey experience
    (Walter De Gruyter Gmbh, 2022) Eren, Erdal; N/A; N/A; N/A; N/A; N/A; Yeşiltepe Mutlu, Rahime Gül; Eviz, Elif; Gökçe, Tuğba; Sakarya, Sibel; Hatun, Şükrü; Faculty Member; Researcher; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; Koç University Hospital; 153511; 327618; N/A; 172028; 153504
    Background: Unlike in Western countries, the use of diabetes technologies has been limited in Turkey, or at least until the last few years. This low adoption frequency may be attributed to the lack of experience of pediatric diabetes teams in working with new technologies. The aim of this study is to evaluate the attitudes, experiences and self-efficacies of pediatric endocrinology fellows and attending physicians in terms of use of continuous subcutaneous insulin infusion (CSII) therapy and continuous glucose monitoring (CGM) systems. Methods: The questionnaire used in this study consisted of 63 questions including 10 questions evaluating the demographic characteristics and experience of the participants, 33 Likert-type questions related to self-competency, 17 yes/no questions and 3 open-ended questions which evaluated attitudes towards our study area. This questionnaire was e-mailed to pediatric endocrinology fellows and attending physicians working in Turkey. Results: A total of 24 fellows and 28 attending physicians working in the field of pediatric endocrinology participated in the survey. Of the respondents, 61% reported that there was no formal training curriculum regarding diabetes technology at their institutions. The mean scores obtained from the Likert scale questions measuring self-competency in using CSII and CGM were 3.8 and 3.3 out of 5, respectively. Of the respondents, 55% judged themselves to be under-skilled in interpreting pump reports while 39% of the respondents reported themselves as being under-skilled in interpreting CGM reports. Conclusions While it is true that training programs for using diabetes technology have been established by the National Pediatric Endocrinology Association in Turkey, the development of a specific curriculum for institutions that provide pediatric endocrinology fellowship training in this framework will increase the self-confidence of pediatric endocrinologists in this matter and this will ultimately contribute to the improvement of the metabolic control of children with diabetes.
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    The my friend diabetes carbohydrate bolus calculator: user experiences
    (Mary Ann Liebert, Inc, 2022) N/A; N/A; Karakuş, Kağan Ege; Gökçe, Tuğba; Can, Ecem; Muradoğlu, Serra Küpçüoğlu; Eviz, Elif; Yeşiltepe Mutlu, Rahime Gül; Hatun, Şükrü; Undergraduate Student; Doctor; Nurse; Doctor; N/A; Researcher; Faculty Member; Faculty Member; School of Medicine; N/A; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; 327618; 153511; 153504
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    Bone age determination in girls with early puberty and limitations of adult height prediction: can automated evaluation (bonexpert (TM)) be a solution?
    (Karger, 2019) N/A; N/A; Yeşiltepe Mutlu, Rahime Gül; Çapacı, Merve; Uzunköprü, Gizem; Hatun, Şükrü; Faculty Member; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; N/A; N/A; 153504
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    Impact of milk as a bedtime snack on nocturnal glycemia in preschool children with Type 1 diabetes: case series
    (Türk Diyetisyenler Derneği, 2020) Gökçe, Tuğba; Yeşiltepe Mutlu, Rahime Gül; Can, Ecem; Eviz, Elif; Muradoğlu, Serra Küpçüoğlu; Hatun, Şükrü; Doctor; Faculty Member; Nurse; Faculty Member; Doctor; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; N/A; 153511; N/A; 327618; N/A; 153504
    Young children with type 1 diabetes (T1D) present special challenges for intensive diabetes management and glycemic variability. Young children face many difficulties in diabetes management, such as having more frequent hypoglycemia and hyperglycemia, lack of awareness of hypoglycemia, less residual beta cell function, severe hypoglycemia and long-term neurocognitive effects due to chronic hyperglycemia. Many parents routinely give bedtime snacks, regardless of glucose value, because of the fear of nocturnal hypoglycemia. Having a habit of drinking milk before sleeping at night is an attitude peculiar to our country. In our clinic, it was observed by examining Continuous Glucose Monitoring (CGM) data that drinking milk at night snacks caused hyperglycemia during the night in young children who were followed-up in our clinic. In case of not drinking milk, it was observed that the course of glucose at night was in the target range (70-180 mg/dL). In this article, the effects of medical and medical nutrition therapy and milk consumption as bedtime snack on CGM data of two patients aged 3-5 years with follow-up in our department is presented. / Öz: Tip 1 diyabet (T1D) tanılı küçük çocuklar diyabet yönetimi ve glisemik değişkenlik bakımından ayrı bir yere sahiptir. Küçük çocuklar (<7 yaş), hipoglisemi ve hipergliseminin daha sık görülmesi, hipoglisemi bulgularını ifade edememeleri, rezidüel beta hücre fonksiyonunun az olması, ciddi hipoglisemi atakları ve kronik hiperglisemiye bağlı uzun dönemde nörokognitif etkilenmenin daha fazla olması gibi birçok zorlukla karşı karşıyadır. Bu zorluklar ebeveynlere endişe olarak yansımakta ve birçok ebeveyn gece hipoglisemisi korkusu nedeniyle glukoz değeri ne olursa olsun rutin bir şekilde çocuğa gece ara öğünü vermektedir. Ülkemizde çocukların gece uyumadan önce ve sabah süt içme alışkanlıkları olması sebebiyle süt sık tüketilen bir seçenek olmaktadır. Kliniğimizde izlenen küçük yaş grubu çocukların Sürekli Glukoz İzlem (SGİ) verilerinde süt içirip uyutmanın gece boyunca hiperglisemiye neden olduğu, süt vermenin bırakılması durumunda ise gece glukoz seyrinin hedef aralıkta (70-180 mg/dL) kalma oranının arttığı gözlenmiştir. Bu yazıda kliniğimizde izlenen 3-5 yaş arasındaki iki olgunun tıbbi beslenme tedavisi ve gece ara öğününde verilen sütün SGİ verilerine yansıması paylaşılacaktır.
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    How do bedtime snack and no snack options affect overnight glycemia in young children with diabetes: preliminary cgm results
    (Mary Ann Liebert, Inc, 2022) Ozel, H. Gokmen; N/A; Gökçe, Tuğba; Hatun, Şükrü; Karakuş, Kağan Ege; Yeşiltepe Mutlu, Rahime Gül; Muradoğlu, Serra Küpçüoğlu; Eviz, Elif; Can, Ecem; Doctor; Faculty Member; Undergraduate Student; Faculty Member; Doctor; Researcher; Other; Koç University Hospital; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; School of Medicine; Koç University Hospital; N/A; 153504; N/A; 153511; N/A; 327618
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    Investigating the nutritional value of foods targeting children
    (Springer, 2020) Guzel, Sumeyye; Keser, Alev; N/A; Hatun, Şükrü; Faculty Member; School of Medicine; 153504
    Purpose This study aimed to investigate the nutritional values of some low-nutrition packaged foods widely sold in supermarkets and encouraged for consumption. Methods The study used 435 packaged foods from six hypermarkets with high sale capacities in Ankara to analyze their contents of energy/total fat/saturated fat/carbohydrate/sugar/salt based on label information. Results Among the products in the scope of the study, the highest values were found in chocolates for fat (33.0 +/- 4.28/100 g) and sugar (45.6 +/- 5.95/100 g), wafers for saturated fat (19.2 +/- 3.89/100 g), and crackers for sodium (0.9 +/- 0.23/100 g). Among the 435 packaged foods investigated in the study, the products exceeded the limits designated in the health codes declared by the Turkish Food Codex Labeling Directive in 83.4% of the instances in terms of sugar, 93.7% of the instances in terms of total fat, 92.4% of the instances in terms of saturated fat, and 70.3% of the instances in terms of sodium. Conclusion Energy/fat/sugar/salt contents were high in the packaged products that are especially targeted for children for higher consumption. Children's frequent and excessive consumption of these products contribute to the prevalence of childhood obesity and increase in related health risks.