Researcher:
Balkancı, Uğur Berkay

Profile Picture
ORCID

Job Title

Undergraduate Student

First Name

Uğur Berkay

Last Name

Balkancı

Name

Name Variants

Balkancı, Uğur Berkay

Email Address

Birth Date

Filters

2019 - 201912020 - 20211

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.e8d41c9d-285c-439b-9de6-4170a84a312c

Search Results

Now showing 1 - 2 of 2
  • Placeholder
    PublicationMetadata only
    A possibly fatal outcome of oral contraceptive therapy: estrogen triggered hereditary angioedema attack in an adolescent
    (Galenos Yayınevi, 2021) Demirkol, Demet; Birben, Esra; Soyer, Özge; N/A; Balkancı, Uğur Berkay; Yeşiltepe Mutlu, Rahime Gül; Yılmaz, Özlem; Saçkesen, Cansın; Undergraduate Student; Faculty Member; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koc University Hospital; N/A; 153511; 140706; 182537
    Hereditary angioedema (HAE) is characterized by recurrent angioedema attacks with no urticaria. This disease has a high mortality due to asphyxia. Level of complement 4 (C4), C1 esterase inhibitor (C1-INH) level and function, and genetic mutations determine different endotypes of HAE. Clinical presentation and the triggers of vasogenic edema may change according to the endotypes. An adolescent girl with oligomenorrhea, obesity, hirsutism, and acanthosis nigricans was diagnosed with polycystic ovary syndrome (PCOS) and prescribed ethinyl estradiol & cyproterone acetate containing oral contraceptive (OC). On the 16th day of treatment, she developed angioedema on the face, neck, and chest leading to dyspnea. Adrenaline, antihistamine, and corticosteroid treatments were ineffective. In the family history, the patient's mother and two cousins had angioedema attacks. C1-INH concentrate was administered with a diagnosis of HAE. C4, and C1-INH level and activity were normal. Genetic analysis identified a mutation of Factor XII (F12) gene, and the diagnosis of Factor 12 (F12)-related HAE was made. OC treatment discontinued. She has had no additional angioedema attacks in the follow-up period of two years. OC containing estrogen may induce the life-threatening first attack of F12-related HAE even in children. Recurring angioedema attacks in the family should be asked before prescribing estrogen-containing OC pills.
  • Placeholder
    PublicationMetadata only
    Co-existence of type 3 hereditary angioedema and polycystic ovary syndrome
    (Wiley, 2019) Birben, E.; Soyer, Uysal O.; Yilmaz, O.; Sackesen, C.; Balkancı, Uğur Berkay; Demirkol, Demet; Yeşiltepe Mutlu, Rahime Gül; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; 108964; 153511
    N/A