Researcher:
Eser, Hale Yapıcı

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Hale Yapıcı

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Eser

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Eser, Hale Yapıcı

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2016 - 2019132020 - 202326

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    Validity and reliability of the Turkish version of Snaith-Hamilton pleasure scale
    (Association for Cognitive and Behavioral Psychotherapies, 2020) Aydemir, Ömer; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Anhedonia is a core feature of many psychiatric disorders and its reliable evaluation is needed for the dimensional understanding of psychiatric disorders. Snaith-Hamilton Pleasure Scale (SHAPS) is one of the most widely used scales to assess anhedonia. Here, we aimed to search the validity and reliability of the Turkish version of SHAPS. Translation of the original scale was completed in a two-step procedure. 188 healthy controls, 56 patients with a depressive disorder (F32-F34, excluding F34.0 cyclothymic disorder, according to ICD-10), and 52 patients with anxiety, stress-related or somatoform disorder diagnoses (F40-49 diagnosis according to ICD-10) were recruited, and evaluated with the Turkish version of SHAPS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Symptom Checklist-90-R (SCL-90-R). For the Turkish version of SHAPS, Cronbach’s alpha coefficient was found 0.87. The item-total item correlation indices ranged from 0.39 to 0.64. Principal components analysis extracted two factors and explained 46.57 % of total variance. The most significant correlation of SHAPS was found with BDI and depression subscale of SCL-90-R scores. SHAPS also weakly but significantly correlated with obsessive compulsive and anxiety subscales of SCL-90-R, and weakly but non-significantly with BAI and somatization, interpersonal sensitivity, hostility and psychoticism subscales of SCL-90-R. Depressive group had significantly higher SHAPS scores compared to controls and anxious group. Anxious group and control group were not significantly different for SHAPS scores. The current study shows that the Turkish version of the SHAPS has good psychometric properties. SHAPS scores may correlate with depression, somatization, and interpersonal sensitivity scores, and it may help to differentiate depressive patients from anxious patients and controls. /Öz: Anhedoni, birçok psikiyatrik bozukluğun temel bir özelliğidir ve psikiyatrik bozuklukların boyutsal olarak anlaşılması için güvenilir bir şekilde değerlendirilmesi gerekir. Snaith-Hamilton Keyif Alma Ölçeği (SHKÖ), anhedoniyi değerlendirmek için en yaygın kullanılan ölçeklerden biridir. Burada, SHKÖ’nün Türkçe versiyonunun geçerliliği ve güvenilirliğinin araştırılması amaçlanmıştır. Orijinal ölçeğin çevirisi iki aşamalı bir prosedürle tamamlanmıştır. 188 sağlıklı kontrol, 56 depresif bozukluk (ICD-10’a göre F34.0 (siklotimi) dışında F32-F34 tanıları almış kişiler) ve 52 anksiyete, stres ilişkili veya somatoform bozukluk tanısı almış olan anksiyöz hasta (ICD-10’a göre F40-49 tanıları almış kişiler) çalışmaya alınmıştır. Katılımcılar SHKÖ’nün Türkçe versiyonu, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Belirti Kontrol Listesi-90-Gözden Geçirilmiş Form (SCL-90-R) ile değerlendirilmiştir. SHKÖ’nün Türkçe versiyonu için Cronbach alfa katsayısı 0,87 olarak bulunmuştur. Madde-toplam madde korelasyon endeksleri 0,39 ile 0,64 arasında değişmiştir. Temel bileşenler analizi iki faktörü ortaya çıkarmış ve toplam varyansın % 46,57‘ sini açıklamıştır. En yüksek SHKÖ korelasyonu BDE ve SCL-90-R‘nin depresyon alt ölçeği skorları ile bulunmuştur. SHKÖ ayrıca SCL-90-R‘nin obsesif kompulsif ve anksiyete alt ölçekleri ile zayıf fakat istatiksel olarak anlamlı bir korelasyon gösterirken, SCL-90- R‘nin somatizasyon, kişilerarası duyarlılık, hostilite ve psikotisizm alt ölçekleri ile zayıf fakat istatistiksel olarak anlamlı olmayan bir ilişki göstermiştir. Depresif hasta grubunda kontrol grubuna ve anksiyöz hasta grubuna göre anlamlı derecede yüksek SHKÖ skorları saptanmıştır. Anksiyöz hasta grubu ve kontrol grubu, SHKÖ skorları için farklı bulunmamıştır. Bu çalışma, SHKÖ’nün Türkçe versiyonunun iyi psikometrik özellikleri olduğunu göstermektedir. SHKÖ puanları depresyon, somatizasyon ve kişilerarası duyarlılık puanları ile ilişkili olabilir ve depresif hastaları anksiyöz hastalardan ve kontrollerden ayırmada yardımcı olabilir.
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    Face memory and emotion recognition in individuals diagnosed with schizophrenia, their unaffected siblings, individuals with ultra-high risk for psychosis and healthy controls
    (Elsevier Science, 2022) Sağdıç, Meylin; İzgi, Büşra; Erciş, Mete; Üçok Alp; Eser, Hale Yapıcı; Kuşçu, Kemal; Doctor; Other; School of Medicine; Koç University Hospital; 134359; N/A
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    FKBP5 methylation, psychiatric disorders and stress: a systematic review and synthesis
    (Elsevier Science Inc, 2022) Çiçek, Yusuf; N/A; İzgi, Büşra; Kuvvet, Yasemin; Musaoğlu, Miraç Nur; Öztosun, Çınar; Eser, Hale Yapıcı; PhD Student; Master Student; PhD Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 134359
    Background FKBP5 methylation levels are among the most studied epigenetic modifications related to psychiatric disorder vulnerability, however there are contradictory findings. We aimed to investigate the role of FKBP5 methylation in psychiatric disorders, in addition to its association with stress exposure (either life adversities, traumatic events or acute stress). Methods In accordance with PRISMA guidelines, ‘FKBP5’ and ‘methylation’ were searched in PubMed and Web of Science in March 2021. 330 studies were identified. Studies on non-psychiatric disorders, animal or cell lines were excluded. Type of study, sample size, sociodemographic properties of the participants, type of stress exposure, type of psychiatric disorder, CPG loci at FKBP5, and other related methods and covariates were extracted from 53 studies found to be eligible based on the inclusion criteria. Results Preliminary analysis showed that 19 studies investigated FKBP5 methylation in psychiatric disorders, 32 studies investigated the effects of stress types on FKBP5 methylation. Among the 197 CpG sites investigated, CpG at chr6:35,590,711 (intron 7), chr6:35,689,425 (promoter region), and chr6:35,590,736 (intron 7/GRE) sites were investigated by 26, 24, and 22 studies, respectively. CpG sites at chr6:35,590,736 and chr6:35,590,711 were reported to be linked to psychiatric disorder; CpG site at chr6:35,590,711, were reported to be linked to types of stress by more than half of the studies that investigated this region. Conclusions The studies on FKBP5 methylation and psychiatric disorder vulnerability are highly heterogeneous and most significant associations are found in intron 7. However, a great percentage of literature report insignificant associations of FKBP5 methylation sites with psychiatric disorder vulnerability.
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    Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study
    (Wiley, 2020) Morey Özcan, Aslıhan; Ongur, Dost; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Taşkıran, Ali Sarper; Ertınmaz, Beliz; Mutluer, Tuba; Kılıç, Özge; Necef, Işıl; Yalçınay-İnan, Merve; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Doctor; Doctor; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; Koç University Hospital; 134359; 195168; N/A; 305311; 167890; N/A; N/A; N/A
    Objective Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD. Method We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted. Results Thirty-seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive-compulsive disorder (OCD) was 16.7%. Childhood-onset studies reported higher GAD and SAD comorbidity, while adolescent-onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders' comorbidity with PBD differently. Conclusion Anxiety disorders are highly comorbid with PBD. Early-onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.
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    The role of chronic stress on mitochondria related neurodegeneration in parkinson's disease
    (Elsevier, 2021) N/A; N/A; N/A; Kuvvet, Yasemin; Atak, Dila; Eser, Hale Yapıcı; Master Student; Master Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; N/A; 134359
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    Development, validity and reliability of the 4-point likert Turkish version of cognitive failures questionnaire
    (İnönü Üniversitesi Tıp Fakültesi, 2020) Aydemir, Ömer; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Aim: Cognitive failures are suggested to be a transdiagnostic endophenotype that increases the vulnerability for psychiatric disorders. Broadbent’s Cognitive Failures Questionnaire (CFQ), is among the most widely used scales to assess cognitive function observed in an ecological manner. Despite its wide use in research and correlation with biological markers, CFQ is criticized for its unstable factorial structure among studies and 5-Likert structure that may lead to bias for neutral answers. Here we aimed to develop a 4-Likert Turkish version of CFQ, search its validity, reliability and factorial structure. Material and Methods: CFQ has been translated to Turkish in two steps. CFQ, Perceived Deficit Questionnaire-D (PDQ-D), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 272 participants (187 healthy controls, 55 patients diagnosed with depression, 30 patients diagnosed with anxiety disorder). Results: The Cronbach’s alpha coefficient of 4-Likert Turkish version of CFQ was found as 0.91. Principal component analysis extracted five factors and explained 53.7 % of total variance. CFQ scores were significantly different among groups. Both depressive and anxious groups reported higher CFQ scores compared to controls. CFQ significantly and strongly correlated with PDQ-D and showed a moderate correlation with BDI and BAI. Conclusion: 4-Likert Turkish version of CFQ is a valid and reliable tool to assess cognitive failures in non-demented groups. Our analysis revealed a five factorial structure for CFQ, however previous literature with the 5-Likert version shows different factor structures and does not indicate a dimensional stability.
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    Effect of GLP-1 agonists use on cognitive and affective functioning in type 2 diabetes mellitus patients: a preliminary study
    (Elsevier Science Inc, 2018) Eren, Candan Yasemin; Sancak, Seda; Yazici, Dilek; Uysal, Sanem Pinar; Whitton, Alexis; Rutherford, Ashleigh; Pizzagalli, Diego; N/A; Eser, Hale Yapıcı; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM; School of Medicine; 134359
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    Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis
    (Cambridge University Press (CUP), 2020) Appadurai, Vivek; Chen, Chia-Yen; Ongur, Dost; Pizzagalli, Diego A.; Werge, Thomas; Hall, Mei-Hua; N/A; Eser, Hale Yapıcı; Eren, Candan Yasemin; Dereli, Dilek Yazıcı; Faculty Member; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 134359; N/A; 179659
    Background: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis. Methods: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis. Results: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis. Conclusion: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.
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    No change in reward responsiveness, but decreased functional connectivity with right nucleus accumbens and left lateral occipital- precuneus cortex 3 months after sleeve gastrectomy
    (Elsevier Science Inc, 2020) Eren, Candan Yasemin; Uymaz, Derya Salim; Yavuz, Yunus; Kılıç, Özge; Eser, Hale Yapıcı; PhD Student; Teaching Faculty; Other; Doctor; Faculty Member; Graduate School of Health Sciences; N/A; School of Medicine; N/A; School of Medicine; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; 175554; N/A; 167890; 134359
    Background: Obesity is known to be linked to nucleus accumbens activity and altered reward responsiveness. Sleeve gastrectomy (SG) is often used for treatment of morbid obesity and activity in the NAcc was shown to positively affect weight-loss at 12 months post-surgery. The aim of this study is to measure the change in reward responses and nucleus accumbens (NAcc) functional connectivity 3 months after SG. Methods: 25 patients with a diagnosis of obesity were evaluated pre-surgery and 3 months post-surgery with Snaith-Hamilton Pleasure Scale (SHAPS), Beck Depression Inventory (BDI) and body weight. As a laboratory-based measure of reward learning, they performed probabilistic reward task (PRT). Resting-state fMRI images were obtained from 7 participants pre and post surgery. Results: Both SHAPS, BDI and response bias and discriminability scores in PRT were not significantly different post-surgery. Mean percentage body weight loss of individuals were 20.07 %. Right NAcc functional connectivity with left lateral occipital- precuneus cortex decreased significantly post-surgery (105 voxels, voxel wise threshold p<0.05, FWE corrected), however no change in left NAcc connectivity was observed. Change in right NAcc functional connectivity was not correlated with weight loss. Conclusions: Previous literature on gambling and alcoholism showed increased NAcc-precuneus connectivity. Functional connectivity decrease between NAcc and precuneus in the resting state can be associated with reduced impulsivity and sensation-seeking observed after BS which correlates positively with successful weight loss.
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    Can we benefit from the preoperative psychometric test with symptom checklist-90-revised (SCL-90-R) to predict weight loss after sleeve gastrectomy?
    (Springer, 2022) Sobutay, Erman; Bilgiç, Çağrı; Şahin, Banu; Mercan, Sibel; Kabaoğlu, Burçak; Yavuz, Yunus; Uymaz, Derya Salim; Eser, Hale Yapıcı; Yavuz, Yunus; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; 175554; 134359; N/A
    Background: The psychological assessment is crucial before bariatric surgery. Derogatis’ Symptom Checklist-90-Revised (SCL-90-R) is one of the most widely used measures of psychological symptoms and distress in both clinical and research settings. We aimed to investigate the predictive value of SCL-90-R subscale scores on postoperative excess weight loss percentage (EWLP) after laparoscopic sleeve gastrectomy (LSG). Methods: Patients who underwent primary LSG for morbid obesity and fully completed preoperative SCL-90-R between January 2016 and July 2019 were retrospectively examined. A multiple linear regression analysis was performed to investigate the relationship between descriptive and psychological variables associated with EWLP percentage at the 12th-month. Results: One hundred six patients who met the inclusion criteria were analyzed. The adequate weight loss (EWLP ˃ 50%) was achieved in 90% of patients after 12 months. The multiple linear regression analysis indicated that younger patients (β =  − 0.695; 95% CI − 1.056, − 0.333; p < 0.001), and patients with preoperative lower BMI (β =  − 1.524; 95% CI − 1.974, − 1.075; p < 0.001) achieved higher EWLP at 12th-month. High somatization score (β = 11.975; 95% CI 3.653, 20.296; p = 0.005) and a low Global Severity Index (GSI) score (β =  − 24.276; 95% CI − 41.457, − 7.095; p = 0.006) had a positive effect on EWLP at 12th-month. Conclusions: Preoperative psychological testing can help predict surgical outcomes in the bariatric population. More intense lifestyle and behavioral support can be applied by targeting patients who are expected to lose less weight after surgery, and patients’ weight loss potential can be increased.