Researcher: Ahıshalı, Emel
Loading...
Name Variants
Ahıshalı, Emel
Email Address
Birth Date
10 results
Search Results
Now showing 1 - 10 of 10
Publication Metadata only The association between irritable bowel syndrome and lactose intolerance(Namık Kemal Üniversitesi, 2019) Dabak, Mustafa Reşat; Küçük, Tuğba Arslan; Tüzün, Sabah; Çetin, Hüseyin; Dolapçıoğlu, Can; Ahıshalı, Emel; Faculty Member; School of Medicine; 216629Aim:Irritable bowel syndrome (IBS) and lactose intolerance (LI) may co-exist and readily cause diagnostic confusion due to similar symptomatology. This study aims to examine the frequency of LI in healthy controls and in participants diagnosed with IBS based on Roma III criteria, as an effort to investigate the association between IBS and LI.Materials and Methods:The patient population consisted of individuals between 18 and 80 years of age who attended between June-December 2013. Patients diagnosed with IBS based on Roma III criteria comprised the IBS group, and subtypes of IBS. Control group was healthy volunteers over 18 years of age with no IBS-like symptoms. All participants ingested 25 g of lactose dissolved in 250 ml of water within 5 minutes after 8 hours of fasting, in order to evaluate the LI via hydrogen breath test (0, 15, 30, 60, 90, and 120 minutes).Results:Of the total 200 participants, 100 (50%) were in the IBS group and 100 (50.0%) were in the control group. of the total 70 patients (35.0%) with LI, 47 (47.0%) were in the IBS group and 23 (23.0%) were in the control group (p=0.001). Symptoms related to IBS were more common in participants with LI in both groups (p=0.001, p=0.001 respectively).Conclusion:A significantly increased frequency of LI was found among IBS patients than in controls. In addition, symptoms associated with lactose intake occurred at a higher frequency in IBS patient, although the difference wasinsignificant. / Amaç: İrritabl barsak sendromu (İBS) ve laktoz intoleransı (Lİ) birlikte görülebilmekte ve aynı zamanda benzer semptomlara neden olabildiği için sıklıkla karışabilmektedir. Bu çalışmada Roma III kriterlerine göre İBS tanısı alan hastalarda ve sağlıklı bireylerde Lİ’nin sıklığı ve İBS ile Lİ ilişkisinin incelenmesi amaçlanmaktadır. Materyal ve Metot: Çalışmaya Haziran-Aralık 2013 tarihleri arasında başvuran 18 – 80 yaş arasındaki hastalar dahil edilmiştir. İBS grubundaki hastalar Roma III kriterlerine göre İBS tanısı konan hastalardan oluşmakta olup, İBS alt tipleri değerlendirilmiştir. Çalışmanın kontrol grubuna ise İBS benzeri şikayetleri olmayan, 18 yaş ve üzerindeki sağlıklı gönüllüler dahil edilmiştir. Tüm katılımcılara 8 saat açlık sonrası 250 ml suda çözündürülen 25 gr laktoz 5 dk’da içirilerek hidrojen nefes testi (0, 15, 30, 60, 90, ve 120 dakikada) ile Lİ değerlendirilmiştir. Bulgular: Çalışmadaki toplam 200 katılımcının 100 (%50.0)’i İBS grubuna ve 100 (%50.0)’i kontrol grubuna dahil edildi. Katılımcıların toplam 70 (%35.0)’inde Lİ mevcut iken İBS grubunda katılımcıların 47 (%47.0)’inde ve kontrol grubundaki katılımcıların 23 (%23.0)’ünde Lİ saptanmıştır (p=0.001). İBS ile ilgili semptomlar her iki grupta Lİ olan katılımcılarda daha yaygın olarak saptanmıştır (sırasıyla, p=0.001 ve p=0.001). Sonuç: İBS hastalarında Lİ kontrol grubuna göre anlamlı yüksek bulunmuştur. Ayrıca, laktoz alımına bağlı semptomlar istatistiksel anlamlı olmamakla beraber İBS grubunda daha sık saptanmıştır.Publication Metadata only Relationship of inflammation and hemogram parameters in the activation of inflammatory bowel diseases(Kafkas Üniversitesi Tıp Fakültesi, 2018) Ahıshalı, Emel; Faculty Member; School of Medicine; 216629Aim: The evaluation of inflammatory bowel diseases (IBD) is based on a combination of clinical examination, laboratory marker and colonoscopic findings. There is no any gold standard test and cost effective, easy applicable markers are required. This present study aimed is determined the relationship between inflamation parameters and hemogram parameters in the IBD. Material and Method: The present study included patients at ≥18 years of age with IBD, who presented between January 2010 and December 2015 and medical records of all patients were retrospectively assessed. Chron Disease (CH) Activity Index for the assessment of activity of CH and SEO Clinical Activity Index for the assessment of activity of ulserative colitis (UC) were used. Additionally, hemogram, C-reactive protein (CRP) and eritrosit sedimentation rate (ESR) of all patients were evaluated. Results: In this study 74 (39.57%) patients with the CD group and 113 (60.43%) patients with the UC group and total of 187 patients with IBD included. Twenty nine (39.19%) patients with CD and 42 (37.17%) patients with UC were in activation period. The platelet count and RDW were found to increase in the activation period of both disease (p=0.001 and p=0.0001 for CD; p=0.001 and p=0.0001 for UC, respectively). In remission period, while there were positive relationship CRP and ESR with platelet counts in the CD group, the positive relationship CRP with leucocyte count was found in the UC group. (p=0.025, p=0.044 and p=0.003 respectively). In the activation period, there were associated CRP and ESR with RDW in the UC group and the correlation between CRP with platelet count in the CD group was determined (p=0.015, p=0.019, and p=0.025, respectively). Conclusion: Platelet count and level of RDW in the hemogram parameters, which a cost effective method for clinical practice, increase in the activation period of CD and UC. / Aim: The evaluation of inflammatory bowel diseases (IBD) is based on a combination of clinical examination, laboratory marker and colonoscopic findings. There is no any gold standard test and cost effective, easy applicable markers are required. This present study aimed is determined the relationship between inflamation parameters and hemogram parameters in the IBD. Material and Method: The present study included patients at ≥18 years of age with IBD, who presented between January 2010 and December 2015 and medical records of all patients were retrospectively assessed. Chron Disease (CH) Activity Index for the assessment of activity of CH and SEO Clinical Activity Index for the assessment of activity of ulserative colitis (UC) were used. Additionally, hemogram, C-reactive protein (CRP) and eritrosit sedimentation rate (ESR) of all patients were evaluated. Results: In this study 74 (39.57%) patients with the CD group and 113 (60.43%) patients with the UC group and total of 187 patients with IBD included. Twenty nine (39.19%) patients with CD and 42 (37.17%) patients with UC were in activation period. The platelet count and RDW were found to increase in the activation period of both disease (p=0.001 and p=0.0001 for CD; p=0.001 and p=0.0001 for UC, respectively). In remission period, while there were positive relationship CRP and ESR with platelet counts in the CD group, the positive relationship CRP with leucocyte count was found in the UC group. (p=0.025, p=0.044 and p=0.003 respectively). In the activation period, there were associated CRP and ESR with RDW in the UC group and the correlation between CRP with platelet count in the CD group was determined (p=0.015, p=0.019, and p=0.025, respectively). Conclusion: Platelet count and level of RDW in the hemogram parameters, which a cost effective method for clinical practice, increase in the activation period of CD and UC. / Amaç: İnflamatuar barsak hastalığı (İBH)’nın değerlendirilmesi klinik muayene, laboratuar belirteçleri ve kolonoskopik bulgulara dayalıdır. Herhangi bir altın standart test yoktur ve maliyet etkin, kolay uygulanabilir belirteçler gereklidir. Bu çalışmada İBH’da inflamasyon parametreleri ile hemogram parametrelerinin ilişkisinin değerlendirilmesi amaçlanmaktadır. Materyal ve Metot: Bu çalışmaya 18 yaş ve üzeri İBH olan, Ocak 2010 Aralık 2015 arasında başvuran hastalar dahil edilmiş ve tüm hastaların tıbbi kayıtları geriye dönük olarak değerlendirilmiştir. Crohn hastalığı (CH) aktivite indeksi CH’nın aktivitesini değerlendirmek için ve SEO klinik aktivasyon indeksi ise ülseratif kolit (ÜK)’nın aktivitesini değerlendirmek için kullanılmıştır. Ayrıca tüm hastaların hemogram, C-reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESH) değerlendirilmiştir. Bulgular: Çalışmaya 74 (%39,57) CH grubunda, 113 (%60,43) ÜK grubunda olmak üzere toplam 187 İBH hastası dahil edilmiştir. CH’ı olan hastaların 29 (%39,19)’u ve ÜK olan hastaların 42 (%37,17)’i aktivasyon döneminde idi. Aktivasyon döneminde her iki grupta da trombosit sayısı ve RDW’de artış saptandı (sırasıyla, CD için p=0,001 ve p=0,0001; ÜK için p=0,001 ve p=0,0001). Remisyon döneminde, CH grubunda CRP ve ESH ile trombosit sayısı arasında pozitif ilişki mevcutken, ÜK grubunda CRP ile lökosit sayısı arasında anlamlı pozitif ilişki saptanmıştır (sırasıyla, p=0,025, p=0,044 ve p=0,003). Aktivasyon döneminde, ÜK grubunda CRP ve ESR ile RDW arasında ilişki mevcut olup, CH grubunda CRP ile trombosit sayısı arasında korelasyon tespit edilmiştir. Sonuç: Klinik pratikte maliyet etkin bir yöntem olan hemogram parametrelerinden trombosit sayısı ve RDW düzeyi CH ve ÜK’in aktivasyon döneminde artmaktadır.Publication Metadata only Hepatitis delta virus epidemiology in the industrialized world(Permanyer Publ, 2020) Toy, Mehlika; Ahıshalı, Emel; Yurtaydın, Süleyman Cihan; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 9509; 189330Within the hepatitis virus landscape, one incomplete virus, the hepatitis delta virus (HDV), appears to differ from hepatitis B and C viruses in the context as it still may not infrequently lead to complications of chronic liver disease and continues to be associated with significant liver-related mortality even when patients have received available treatment for it. Breakthrough therapies are so far lacking for HDV-infected patients and treatment has not changed since the discovery of HDV in 1977 and consists mainly of interferons. While there was little interest on the global epidemiology of HDV until recently, this has changed in the past 2 years and we are currently observing a stream of papers on the global epidemiology of HDV and commentaries about why prevalence estimates appear to differ so dramatically. This may be related to the fact that reliable data are not available for most of the countries. However, in the industrialized world, data on the epidemiology of HDV are expected to be of better overall quality. Hence, this review was undertaken to provide a detailed overview on the epidemiology of HDV infection in industrialized countries using data from representative larger countries. In industrialized countries, with maybe the exception of China, HDV infection is a disease of high-risk groups. Migrant groups and people who inject drugs are the most encountered high-risk groups. This review summarizes the dynamics of their contribution to the HDV epidemiology in industrialized countries of the west and the east.Publication Metadata only Endoscopic sleeve gastroplasty for obesity: a multicenter study of 248 patients with 24 months follow-up(Aves, 2018) Ahıshalı, Emel; Faculty Member; School of Medicine; 216629Publication Metadata only Evaluation of the relationship between gastroesophageal reflux disease and helicobacter pylori(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, 2021) Emre, Emre; Emre, Şahika Sümer; Ahıshalı, Emel; Faculty Member; School of Medicine; 216629Objectives: Helicobacter pylori (HP) is a gram-negative, microaerophilic bacterium that causes stomach infections. Gastroesophageal Reflux Disease (GERD) is one of the most common gastrointestinal disorders in the population, and its relationship with HP infection is still controversial. Although there are some articles in the literature that support the onset of esophagitis in patients with HP, a clear causal relationship between GERD and HP infection has not yet been established. The aim of this study is to evaluate the relationship between GERD and HP infection Materials and Methods: The files and gastroscopy reports of 1549 patients who underwent upper GIS endoscopy in the Gastroenterology Unit were evaluated. In addition to clinical features, 536 patients endoscopically diagnosed with GERD were included in the study. Endoscopy and pathology reports of 536 patients diagnosed with GERD were evaluated and analyzed for HP, esophagitis and intestinal metaplasia. Results: HP positivity was found in 229 (42,72%) of 536 patients diagnosed with GERD. Esophagitis was detected in 7,42% of patients with HP positive, and 13,35% of patients with HP negative had esophagitis. The frequency of esophagitis was found to be statistically significantly lower in those with positive HP (p=0,026). Conclusion: We found that patients with negative HP had significantly frequent reflux-esophagitis. This finding was consistent with the literature supporting the opposite relationship between HP and reflux-esophagitis. In the light of the knowledge obtained from the literature, it is thought that HP eradication in all patients with GERD will not reduce symptoms or may increase it. / Amaç: Helicobacter pylori (HP) midede enfeksiyona neden olan gram negatif mikroaerofilik bir bakteri türüdür. Gastroözofageal Reflü Hastalığı (GÖRH) toplumdaki en yaygın gastrointestinal rahatsızlıklardan biridir ve HP enfeksiyonu ile arasındaki ilişki ise hala tartışma konusudur. Literatürde, HP ile enfekte olan hastalarda özofajit başlangıcını destekleyen bazı makaleler olmasına rağmen, GÖRH ve HP enfeksiyonu arasında net bir nedensel ilişki henüz kurulmamıştır. Bu çalışmanın amacı, GÖRH ile HP enfeksiyonu arasındaki ilişkiyi değerlendirmektir. Materyal ve Metot: Dr.Lütfi Kırdar Kartal EAH Gastroenteroloji Ünitesinde üst GİS endoskopisi yapılan 1549 hastanın dosyaları ve gastroskopi raporları değerlendirildi. Klinik özelliklerin yanı sıra endoskopik olarak GÖRH tanısı koyulmuş 536 hasta çalışmaya dahil edildi. GÖRH tanısı konulmuş 536 hastanın endoskopi ve patoloji raporları taranarak HP, özofajit ve intestinal metaplazi açısından analiz edildi. Bulgular: GÖRH tanısı konan 536 hastanın 229’unda (%42,72) HP pozitifliği saptandı. HP pozitif olan hastaların %7,42’sinde özofajit saptandı, HP negatif olan hastaların ise %13,35’inde özofajit vardı. HP pozitif olanlarda özofajit sıklığı istatiksel olarak anlamlı düşük bulundu (p=0,026). Sonuç: HP negatif olan hastalarda anlamlı derecede sık reflü-özofajit olduğunu gördük. Bu bulgu HP ile reflüözofajit arasındaki zıt ilişkiyi destekleyen literatür ile uyumluydu. Literatürden edinilen bilgi birikimi ışığında GÖRH olan tüm hastalarda HP eradikasyonunun, bir grup hastada semptomları geriletmeyeceği belki de arttırabileceği düşünülmektedir.Publication Metadata only Irritable bowel syndrome in multiple sclerosis patients and its relation to attacks(Dicle Üniversitesi, 2021) Demiral, Gökçe Zeytin; Börü, Ülkü Türk; Bölük, Cem; Demiral, Bahadır H.; Taşdemir, Mustafa; N/A; Ahıshalı, Emel; Duman, Sanem Coşkun; Faculty Member; Researcher; School of Medicine; School of Medicine; 216629; N/AObjective: Knowledge about bidirectional microbiome-gut-brain interactions has gradually increased in multiple sclerosis (MS) and many other diseases. The aim of this study is to determine the prevalence of irritable bowel syndrome (IBS) in MS patients, to compare with a control group and to identify the relationship between MS attacks and gastrointestinal (GI) symptoms. Methods: Patients with at least a two-year diagnosis of relapsing-remitting MS (RRMS) from our outpatient clinic were included in the study. The duration of disease, expanded disability status scale and time of MS attacks were recorded. ROME- IV criteria were used for diagnosis of IBS. Results were compared with the control group. IBS symptoms prior to, during and after an attack were recorded and their relationship to MS attacks was investigated. Results: 93 RRMS patients and 101 controls were included in this study. The prevalence rate of IBS was found to be 16.1% (n=15) in MS patients and 8.9% (n=9) in the control group. No significant difference can be found in IBS prevalence rate between MS patients and controls (p=0.127). MS attacks had no significant effect on constipation, diarrhea, abdominal pain and distention. Conclusion: This study showed that MS patients have a similar IBS prevalence to the control group. In addition, MS attacks have no significant effect on GI symptoms. / Amaç: Multipl skleroz (MS) ve diğer hastalıklarda; mikrobiyom-barsak ve beynin iki yönlü etkileşimi konusundaki bilgi birikimi giderek artmaktadır. Bu çalışmanın amacı MS hastalarında irritabl barsak sendromu prevalansını belirlemek, kontrol grubu ile karşılaştırmak ve MS atakları ile gastrointestinal semptomlar arasındaki ilişkiyi belirlemektir. Yöntemler: Kliniğimizce en az 2 yıldır yineleyici MS (RRMS) teşhisi ile izlenen hastalar çalışmaya dâhil edildi. Hastalık süresi, özürlülük skalası (EDSS) ve MS atak zamanları kaydedildi. Irritabl barsak sendromu tanısında Roma-IV kriterleri kullanıldı. Sonuçlar kontrol grubu ile karşılaştırıldı. MS atakları öncesindeki, atak sırasındaki ve sonrasındaki gastrointestinal semptomlar kaydedilerek MS atakları ile ilişkisi araştırıldı. Bulgular: 93 RRMS hastası ve 101 kontrol çalışmaya dâhil edildi. MS hastalarında irritabl barsak sendromu prevalansı %16,1 (n=15) bulunurken, kontrol grubunda %8,9 (n=9) bulundu. İrritabl barsak sendromu sıklığı açısından MS hastaları ve sağlıklı kontroller arasında istatistiksel olarak anlamlı farklılık izlenmedi (p=0,127). MS ataklarının ishal, kabızlık, şişkinlik ve karın ağrısı üzerine anlamlı etkisi bulunamadı. Sonuç: Bu çalışma MS hastalarındaki irritabl barsak sendromu sıklığının sağlıklı kontroller ile benzer olduğunu göstermiştir. Ayrıca MS ataklarının gastrointestinal semptomlar üzerine anlamlı etkisi yoktur.Publication Open Access Regional epidemiology, burden, and management of hepatitis B virus in the Middle East(Wiley, 2019) Akyıldız, Murat; Ahıshalı, Emel; Zeybel, Müjdat; Yurtaydın, Süleyman Cihan; Faculty Member; Faculty Member; Faculty Member; School of MedicinePublication Open Access A new risk-scoring system for colorectal cancer and polyp screening by Turkish Colorectal Cancer and Polyp Study Group(Aves, 2022) Erdem, L.; Akbal, E.; Koçak, E.; Tucer, D.; Üçbilek, E.; Uyanıkoğlu, A.; Dolapçıoğlu, C.; Şirin, G.; Alkım, H.; Soylu, A.; Doğanay, L.; Kürbüz, A.K.; Özdil, K.; Alagözlü, H.; Erürker Öztürk, T.; Sezikli, M.; Adalı, G.; Çoban, M.; Hülagü, S.; Değertekin, H.; Atasoy, A.; Akyüz, F.; Gaffarlı, İ.; Saruç, M.; Altıntaş, E.; Sezgin, O.; Tözün N.; Ahıshalı, Emel; School of MedicineBackground: colorectal cancer is one of the most commonly diagnosed types of cancer worldwide. An early diagnosis and detection of colon cancer and polyp can reduce mortality and morbidity from colorectal cancer. Even though there are a variety of options in screening tests, the question remains on which test is the most effective for the early detection of colorectal cancer. In this prospective study, we aimed to develop a simple, useful, effective, and reliable scoring system to detect colon polyp and colorectal cancer. Methods: we enrolled 6508 subjects over the age of 18 from 16 centers, with colonoscopy screening. The age, smoking status, alcohol consumption, body mass index, polyp incidence, polyp size, number and localization, and pathologic findings were recorded. Results: the age, male gender, obesity, smoking, and family history were found as independent risk factors for adenomatous polyp. We have developed a new scoring system which can be used for these factors. With a score of 4 or above, we found the following: sensitivity 81%, specificity 40%, positive predictive value 25.68%, and negative predictive value 89.84%, for adenomatous polyp detection; and sensitivity 96%, specificity 39%, positive predictive value 3.35%, negative predictive value 99.29%, for colorectal cancer detection. Conclusion: even though the first colorectal cancer screening worldwide is generally performed for individuals over 50 years of age, we recommend that screening for colorectal cancer might begin for those under 50 years of age as well. Individuals with a score ? 4 must be included in the screening tests for colorectal cancer.Publication Open Access The prevalence of metabolic-associated fatty liver disease in the Turkish population: a multicenter study(Kare Yayıncılık, 2021) Yılmaz, Yusuf; Yılmaz, Nimet; Ateş, Fehmi; Karakaya, Fatih; Gökcan, Hale; Kaya, Eda; Adali, Gupse; Kartal, Aysun Çalışkan; Şen, İlker; Özdemir, Seren; Koruk, Mehmet; Uygun, Ahmet; İdilman, Ramazan; Turkish Association for the Study of the Liver (TASL), Fatty Liver Diseases Special Interest Groups; Ahıshalı, Emel; Faculty Member; School of MedicineBackground and aim: the objective of the present study was to investigate the prevalence of metabolic-associated fatty liver disease (MAFLD) in patients with dyspepsia. Materials and methods: a total of 909 consecutive patients who presented with dyspepsia at 8 tertiary care centers in Turkey between March 2019 and December 2019 were included. Results: the median age was 47 years. Among them, 30.3% of the patients were obese, 18.8% had type 2 diabetes mellitus (T2DM), 35.1% had metabolic syndrome, 84.8% had dyslipidemia, and 23.9% had hypertension. The prevalence of MAFLD was 45.5%. Among the patients with MAFLD, the prevalence of obesity, T2DM, metabolic syndrome, dyslipidemia, and hypertension was 43.3%, 24.9%, 52.5%, 92.3%, and 31.9%, respectively. MAFLD was significantly associated with all of the metabolic comorbidities (p<0.001). The median Fibrosis-4 Index score of the MAFLD patients was 0.88 (range: 0.1–9.5). Of note, 53 patients with hepatic steatosis did not meet the MAFLD criteria. Conclusion: the results of the present study indicated that there was a significantly high prevalence of MAFLD observed in daily clinical practice in Turkey. Early diagnosis and prevention efforts should be implemented to reduce disease progression, and a region-based strategy is recommended.Publication Open Access Upper socioeconomic status is associated with lower Helicobacter pylori infection rate among patients undergoing gastroscopy(The Journal of Infection in Developing Countries, 2020) Mungan, Zeynel; Attila, Tan; Zeybel, Müjdat; Yiğit, Yeşim Esen; Baran, Bülent; Ahıshalı, Emel; Alper, Emrah; Aslan, Fatih; Ergönül, Önder; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; 118342; 214694; N/A; 167583; N/A; N/A; 219202; 110398Introduction: socioeconomic factors play an important role in the prevalence of Helicobacter pylori (HP) infection. The aim of this study is to investigate HP prevalence among symptomatic patients in the upper socioeconomic segment of the population undergoing gastroscopy in an endemic urban region. Methodology: over a 12-month period, data were collected from the first consecutive 1000 patients (500 from university hospital, 500 from community hospital) who had gastroscopy and HP evaluation. Results: overall, 211/1000 patients (21.1 %) were found to have HP in gastric biopsies. The specificity, sensitivity, positive predictive value, negative predictive value and diagnostic accuracy of rapid urease test were 87.5%, 99.7%, 99%, 96.5%, and 96.9% respectively. Atrophic gastritis, gastric and duodenal ulcers were significantly more common in HP positive patients. Age based distribution of HP prevalence: > 6 decades (15.5%), 3rd-5th decades (26.1%), < 3rd decades (10.4%). Conclusion: in an HP endemic country, the prevalence of HP infection among symptomatic patients belonging to the upper socioeconomic segment of the population appears to be markedly lower. The lowest prevalence in young patients is expected to result in future decrease in HP prevalence.