Researcher:
Özel, Melis

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Undergraduate Student

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Melis

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Özel

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Özel, Melis

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2019 - 201912020 - 20212

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    HIV as a chronic disease: are primary care physicians ready?
    (DOC Design and Informatics, 2020) Çınar, Güle; N/A; Eren, Özgür Can; Özel, Melis; Ergönül, Önder; Researcher; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 110398
    Objective: As HIV infection is becoming a chronic entity, the role of primary care physicians (PCPs) in diagnosis and treatment is getting more significant. We aimed to assess the attitude and competency of the PCPs about HIV infection compared to other specialties and describe the areas for improvement. Materials and Methods: A survey was conducted between 1-31 May 2017 among physicians from different specialties. The questions related to HIV infection in their clinical practice, competency, and knowledge about the transmission and preventability of the disease and their attitude towards suspected patients were asked. Results: We included 492 physicians in the study, consisting of PCPs (32%), infectious disease specialists (IDSs) (13%), internal medicine specialists (IMSs) (30%) and surgeons (25%), practicing in 25 different cities in Turkey. When asked about HIV, 98% of IDSs considered it as a chronic disease, with 35% thinking that it is similar to non-communicable disease (Diabetes Mellitus, Hypertension, Lymphoma). HIV was not a curable disease according to 87% of PCPs, and 21% in IDSs. The 70% of PCPs thought that HIV infection could be transmitted with vectors (p<0.001, although they self-rated their knowledge above the average. According to 34% of PCPs, HIV was transmissible through shared utensils (spoon, fork, glass), according to 50% public pools and toilets could be a source for transmission (p<0.001) Upon diagnosis, only 53% of IDSs provided psychological support to patients, and this rate declined to 1% in PCPs (p<0.001). Conclusion: The potential role of PCPs in the follow up of HIV infected patients would be increased. However, there are significant knowledge and attitude gaps related to HIV infection among PCPs in Turkey. By thinking of increasing the role of primary care, training, and education programs should be implemented for PCPs.
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    Defining a new variable that may impact long-term postoperative nasal tip support the biomechanical properties of the columellar strut graft
    (Lippincott Williams and Wilkins (LWW), 2019) Layegh, Ehsan; N/A; N/A; Department of Mechanical Engineering; N/A; N/A; N/A; N/A; Sezgin, Billur; Güney, Kırdar; Lazoğlu, İsmail; Tatar, Sedat; Özel, Melis; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Doctor; Faculty Member; N/A; Undergraduate Student; Faculty Member; Other; Department of Mechanical Engineering; School of Medicine; N/A; College of Engineering; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 133762; N/A; 179391; N/A; N/A; 125951; N/A
    Background: Although columellar strut grafts (CSGs) are considered among the fundamental steps for providing nasal tip support, a downward rotation of the nasal tip in patients with strut grafts can still be encountered. Patient-related factors such as nasal skin thickness can allow the plastic surgeon to anticipate certain drawbacks that can be encountered in the healing phase, but patient-based differences of nasal cartilage and the resulting impact have yet to be investigated. The purpose of this study was to evaluate the effect of the biomechanical properties of CSGs on late postoperative nasal tip position and support. Methods: The study was undertaken with the participation of 20 patients undergoing closed-technique primary rhinoplasty with CSGs. Each cartilage specimen was biomechanically analyzed to calculate the modulus of elasticity. Preoperative and postoperative images were obtained to determine nasal tip position and rotation with quantitative measurements. Postoperative 3- and 12-month measurements were evaluated according to their relationship with the elasticity modulus of the utilized cartilages. Results The evaluation demonstrated that the elasticity modulus can impact the long-term support of the nasolabial angle in which an increase in the coefficient of elasticity can result in a decrease in long-term nasal tip support. Conclusion: The results of the study reveal a new objective variable that can impact nasal tip dynamics and patient-related differences following rhinoplasty. This study not only brings forth a different perspective in the evaluation of nasal tip dynamics but can also provide data for determining ideal values for cartilage prefabrication.
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    PublicationOpen Access
    Can remote ischemic preconditioning counteract the renal functional deterioration attributable to partial nephrectomy under warm ischemia? results of an animal study
    (BioMed Central, 2021) Uhlig, Annemarie; Mut, Tuna Till; Kanbay, Mehmet; Baydar, Dilek Ertoy; Acar, Ömer; Taşkın, Ali Cihan; Esen, Tarık; Armutlu, Ayşe; İncir, Said; Ertuğlu, Lale Aslıhan; Özel, Melis; Faculty Member; Faculty Member; Faculty Member; Other; Faculty Member; Teaching Faculty; Faculty Member; Undergraduate Student; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 110580; 8025; 237530; 291296; 50536; N/A; N/A; N/A; N/A
    Background: to investigate if remote ischemic preconditioning (RIPC) can offer any renoprotective value by counteracting the deleterious effect of partial nephrectomy (PN) under warm ischemia on renal function. Methods: four groups, each with 5 Wistar albino rats, were constructed; RIPC + PN, PN, RIPC and sham. Right nephrectomy was performed to constitute a solitary kidney model. RIPC denoted sequential clamping/declamping of the femoral artery/vein complex. PN was performed under warm-ischemia following RIPC. Blood samples were collected on multiple occasions until euthanasia on day 7. Immunoassays were conducted to measure the serum and tissues levels of kidney injury markers. Kidneys were examined histologically and morphometric analyzes were performed using digital scanning. Results: IL-33 levels did not differ significantly between the groups. Serum levels of KIM-1, NGAL, and aldose reductase in RIPC + PN, PN and RIPC groups were significantly lower than that of sham group. Tissue biomarker levels were similar across groups. The observed trend in mean necrosis area of PN group was higher than that of RIPC + PN group (p > 0.05). The transitional zone between necrosis and healthy tissue showed a trend towards increasing width in the rats subjected to RIPC before PN vs. those who underwent PN without RIPC (p > 0.05). Conclusion: RIPC failed to counteract the renal functional consequences of PN under warm ischemia in a solitary kidney animal model. The supportive but marginal histological findings in favor of RIPC's renoprotective potential were not supplemented with the changes in serum and tissue biomarker levels.