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Şentürk, Begüm Güler

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Begüm Güler

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Şentürk

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Şentürk, Begüm Güler

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2021 - 20225

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    Dietary patterns and eating behaviors on the border between healthy and pathological orthorexia
    (Springer, 2022) Şentürk, Erman; Geniş, Bahadır; Coşar, Behçet; N/A; N/A; Şentürk, Begüm Güler; Erus, Suat; Researcher; Faculty Member; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; 327593; 175565
    Purpose: The obsession with healthy eating associated with restrictive behaviors is called Orthorexia Nervosa (OrNe). Nevertheless, some studies suggest that orthorexia can also be a non-pathological interest in healthy eating which is called Healthy Orthorexia (HeOr). First, one of the main objectives of this study is to compare HeOr, OrNe and eating behaviors in different dietary patterns (vegan, vegetarian and omnivore). Second is to reveal the relationship between HeOr, OrNe and eating behaviors (cognitive restraint, uncontrolled eating, and emotional eating). Lastly, to determine the potential predictors of HeOr and OrNe. Methods: Participants (N = 426 with an omnivorous diet; N = 415 with a vegan diet, N = 324 with a vegetarian diet) completed a web-based descriptive survey, the Teruel Orthorexia Scale and the Three-Factor Eating Questionnaire-R 21. Results: HeOr and OrNe were more common in individuals following both vegan and vegetarian diets. Individuals following a vegan or a vegetarian diet had lower body mass index and higher body image satisfaction than individuals following an omnivorous diet. Cognitive restraint and following a vegan or a vegetarian diet were the two main predictors of both HeOr and OrNe. Cognitive restraint was positively associated with both HeOr and OrNe (more strongly correlated with OrNe), whereas uncontrolled eating and emotional eating behaviors were positively related to OrNe and negatively related to HeOr. Conclusion: The present study contributes to a better understanding of the some similarities and differences between HeOr and OrNe. It also points to higher rates of orthorexia in individuals following a vegan or vegetarian diet and represents a further step towards developing prevention and intervention programs by identifying risk factors for OrNe.
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    Association between high initial CEA, CA 19-9 levels and HER-2 status and their prognostic values on overall survival in metastatic gastric cancer
    (Zerbinis Publications, 2021) Tural, Deniz; Selçukbiricik, Fatih; Ertürk, Kayhan; Balık, Emre; Kuvvet, Fadime Buket Bayram; Celayir, Özde Melisa; Babashov, Farid; Şentürk, Begüm Güler; Mandel, Nil Molinas; Faculty Member; Faculty Member; Faculty Member; Doctor; Doctor; Doctor; Researcher; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 202015; N/A; 18758; 176242; 329382; N/A; 327593; 194197
    Purpose: This study aimed to investigate the correlations between baseline levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) and immunohistochemical (IHC), Human epidermal growth factor receptor (HER-2) expressions; and question their prognostic values in patients with metastatic gastric cancer. Methods: Gastric cancer patients were retrospectively analyzed. Demographic information, clinical stages, immunohistochemical HER-2 expressions and serum CEA, serum CA 19-9 levels were evaluated at the time of diagnosis. The correlations between HER-2 IHC expressions and the initial marker levels were assessed, and survival analyses were performed. Results: A total of 411 patients were included in the study. Median age of patients was 58 years (range: 22-90); males: 297 (72.3%); females: 114 (27.7%). Median overall survival (OS) was 24 months (range: 19-29). Patient HER-2 IHC expression 0, 1, 2, 3 ratios were 43, 22, 16, and 19%, respectively. At the time of diagnosis, the median value of CEA was 4 (range: 3-5), and the median value of CA 19-9 was 18 (range: 14-22). The increase in CEA and CA 19-9 levels were correlated with the increase of IHC levels (p=0.0001). OS of patients with high initial CEA levels (>5 ng/mL) were significantly shorter than those with low initial CEA levels (<5 ng/mL). Conclusion: Significant positive correlations were shown between HER-2 IHC expressions and CEA, CA 19-9 levels. Baseline CEA, CA 19-9 levels predicted HER-2 positivity and this directly affected treatment and OS.
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    PublicationOpen Access
    Granulomatosis with Poliangiitis (GPA)
    (Hacettepe Tıp Fakültesi, 2021) Kanıtez, Nilüfer Alpay; Şentürk, Begüm Güler; Faculty Member; Researcher; School of Medicine; 239432; 327593
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    PublicationOpen Access
    The speed of ingestion of a sugary beverage has an effect on the acute metabolic response to fructose
    (Multidisciplinary Digital Publishing Institute (MDPI), 2021) Afşar, Barış; Covic, Adrian; Andres-Hernando, Ana; Sanchez-Lozada, Laura Gabriela; Lanaspa, Miguel A.; Johnson, Richard J.; Kanbay, Mehmet; Baygül, Arzu Eden; Şentürk, Begüm Güler; Ertuğlu, Lale Aslıhan; Dağel, Tuncay; İncir, Said; Faculty Member; Researcher; Undergraduate Student; Doctor; Faculty Member; School of Medicine; Koç University Hospital; 110580; 272290; 327593; N/A; N/A; N/A
    Background: the consumption of sweetened beverages is associated with increased risk of metabolic syndrome, cardiovascular disease, and type 2 diabetes mellitus. Objective: we hypothesized that the metabolic effects of fructose in sugary beverages might be modulated by the speed of ingestion in addition to the overall amount. Design: thirty healthy subjects free of any disease and medication were recruited into two groups. After overnight fasting, subjects in group 1 drank 500 mL of apple juice over an hour by drinking 125 mL every 15 min, while subjects in group 2 drank 500 mL of apple juice over 5 min. Blood samples were collected at time zero and 15, 30, 60, and 120 min after ingestion to be analyzed for serum glucose, insulin, homeostatic model assessment (HOMA-IR) score, fibroblast growth factor 21, copeptin, osmolarity, sodium, blood urea nitrogen (BUN), lactate, uric acid, and phosphate levels. Results: serum glucose, insulin, HOMA-IR, fibroblast growth factor 21, copeptin, osmolarity, sodium, BUN, and lactate levels increased following apple juice ingestion. The increases were greater in the fast-drinking group, which were more significant after 15 min and 30 min compared to baseline. The changes in uric acid were not statistically different between the groups. Phosphate levels significantly increased only in the fast-drinking group. Conclusion: fast ingestion of 100% apple juice causes a significantly greater metabolic response, which may be associated with negative long-term outcomes. Our findings suggest that the rate of ingestion must be considered when evaluating the metabolic impacts of sweetened beverage consumption.
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    PublicationOpen Access
    Determinants of pancreatic steatosis: a retrospective observational study
    (Iranian Association of Gastroenterology and Hepatology, 2021) Siriopol, Dimitrie; Sag, Alan A.; Afşar, Barış; Covic, Adrian; Johnson, Richard J.; Altınmakas, Emre; Şentürk, Begüm Güler; Çöpür, Sidar; Güneyli, Serkan; Doğan, Hakan; Balık, Emre; Kanbay, Mehmet; Other; Researcher; Researcher; Researcher; Faculty Member; Faculty Member; School of Medicine; N/A; 327593; 368625; 36622; 327614; 18758; 110580
    Backgroud: metabolic syndrome affects 35% of the adult population in developed countries associated with non-alcoholic steatohepatitis, insulin resistance, and cardiovascular events. Fatty infiltration of the pancreas, or pancreatic steatosis, is a risk factor for acute pancreatitis, pancreatic malignancies, and diabetes mellitus, yet its relationship with metabolic syndrome is not well defined. Methods: we performed a single-centered retrospective observational study of 322 healthy subjects (subjects volunteering to be kidney transplant donors, mean age=46.3±13.5, 163 men and 159 women) in the last 2 years (July 2018-February 2020) from our institution. Pancreatic steatosis and hepatosteatosis were confirmed by computed tomography. Results: pancreatic steatosis was present in 26.3% (85/322) of the subjects, and this finding correlated with age, body mass index (BMI), male sex, a family history of diabetes, creatinine, cystatin C, uric acid, low-density lipoprotein (LDL) cholesterol, triglycerides, glycemia, hemoglobin, transverse body diameter, and subcutaneous fat thickness levels by univariable logistic regression. On multiple linear regression only age (95% CI 1.01, 1.06), BMI (95% CI 1.01, 1.19), male sex (95% CI 1.49-5.99), uric acid (95% CI 1.01, 1.76), and subcutaneous fat thickness levels (95% CI 1.21-2.36) remained independently associated with pancreatic steatosis. Conclusion: pancreatic steatosis is common and associated with obesity, elevated serum uric acid, subcutaneous fat thickness, and male sex. Future studies are needed to evaluate if there are specific clinical consequences to the presence of pancreatic steatosis.