Researcher:
Ceylan, Deniz

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Faculty Member

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Deniz

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Ceylan

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Ceylan, Deniz
Özalp, Deniz Ceylan Tufan

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2020 - 202318

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Researcher Of Publications: search.filters.isAuthorOfPublication.ff599bf2-6d7d-4729-b2cb-eccf65faa487

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Now showing 1 - 10 of 18
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    Expressions of dna base excision genes in unipolar and bipolar depression
    (2022) Yılmaz, Selda; Akan, Pınar; Özerdem, Ayşegül; N/A; Ceylan, Deniz; Baysal, Kemal; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 137755; 119184
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    A postgraduate training program for early career psychiatrists serving patients with bipolar disorder
    (Wiley, 2022) Ceylan, Deniz; Yorguner, Nese; Tan, Devran; Altinbas, Kursat; Cakir, Sibel; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
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    A case-control candidate gene study on base excision repair mechanism (BER) as a novel therapeutic target in bipolar disorder
    (Wiley, 2022) Ozerdem, Aysegul; Veldic, Marin; Singh, Balwinder; Frye, Mark; Schulze, Thomas; Biernacka, Joanna; Winham, Stacey J.; N/A; Ceylan, Deniz; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 137755
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    Neurocognitive profiles of bipolar disorder patients receiving olanzapine or quetiapine in addition to mood-stabilizers
    (Elsevier, 2021) Erdogan, A.; Hidiroglu, C.; Ozerdem, A.; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
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    Quality of life of individuals with bipolar disorder and schizophrenia
    (Türk Nöropsikiyatri Derneği, 2022) Celik, Hidayet Ece Arat; Bagci, Basak; Akdede, Berna Binnur; Alptekin, Koksal; Ozerdem, Aysegul; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
    Introduction: Quality of life (QoL) is a concept defined as a subjective perception of one's position in life and is negatively affected in many psychiatric illnesses such as bipolar disorder (BD) and schizophrenia (SCZ). It is hypothesized that therapeutic approaches based on QoL can increase the patient's adherence to treatment and contribute to a satisfactory life. This study aimed to compare the QoL of individuals having BD and schizophrenia with that of healthy controls (HCs) and to investigate the impact of the state of remission on QoL.Method: The World Health Organization QoL Scale-Short Form (WHOQOL-Bref) was administered to individuals with BD (n=124) and SCZ (n=74) and to HCs (n=81) to evaluate QoL. The WHOQOL-Bref subscale and total scores were compared between the groups using multifactor analysis of covariance (MANCOVA) by considering age and education level as the covariates. Then, the patient groups were compared using MANCOVA based on the state of remission by taking age, level of education, and Global Assessment of Functioning scores as the covariates. The relationship between clinical features and QoL scores was evaluated using correlation analysis, and linear regression analysis was applied for the variables that were found to be significant.Results: It was found that individuals with SCZ or BD had lower WHOQOL-Bref psychological, social, and total scores than HCs. Those with SCZ additionally had lower physical and environmental subscale scores than HCs. Furthermore, those with SCZ had lower WHOQOL-Bref physical, psychological, social, and total scores than individuals with BD. There was no significant difference in WHOQOL-Bref scores between individuals with BD and SCZ in the remission period. WHOQOL-Bref physical, psychological, and total scores were found to be significantly lower in unremitted BD patients when compared with remitted BD patients. Unremitted BD patients were found to have significantly lower WHOQOL-Bref psychological, environmental, and total scale scores than unremitted SCZ patients. Conclusion: It can be concluded that the QoL of individuals with BD is between that of healthy individuals and those with SCZ. However, unremitted BD patients have lower QoL than unremitted SCZ patients. Both patient groups display similar features during remission. Identifying the similarities and differences in terms of QoL in both patient groups is of great importance to develop the best type of treatment for the patients.
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    Clinical and developmental characteristics of cognitive subgroups in a transdiagnostic sample of schizophrenia spcectrum disorders and bipolar disorder
    (Elsevier B.V., 2023) Bora, E.; Verim, B.; Akgul, O.; Ildız, A.; Alptekin, K.; Özerdem, A.; Akdede, B. B.; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
    Evidence suggests that neurocognitive dysfunction is a transdiagnostic feature of individuals across the continuum between schizophrenia and bipolar disorder. However, there is significant heterogeneity of neuropsychological and social-cognitive abilities in schizophrenia, schizoaffective disorder, and bipolar disorder. The current study aimed to investigate the clinical and developmental characteristics of cognitive subgroups within the schizo-bipolar spectrum. 147 clinically stable patients with schizophrenia, schizoaffective or bipolar disorder were assessed using clinical rating scales for current psychotic and affective symptoms, and a comprehensive neuropsychological battery including measures of social cognition (Hinting and Reading the mind from the Eyes (RMET) task)). Developmental history and premorbid academic functioning were also evaluated. The study also included 36 healthy controls. Neurocognitive subgroups were investigated using latent class analysis (LCA). The optimal number of clusters was determined based on the Bayesian information criterion. A logistic regression analysis was conducted to investigate the predictors of membership to the globally impaired subgroup. LCA revealed two neurocognitive clusters including globally impaired (n = 89, 60.5%) and near-normal cognitive functioning (n = 58, 39.5%) subgroups. The near-normal cognitive functioning subgroup was not significantly different from healthy controls. The globally impaired subgroup had a higher score of developmental abnormalities (p<0.001), poorer premorbid academic functioning, mothers who were less educated and more severe disorganized speech (p = 0.001) and negative symptoms (p = 0.004) compared to the near-normal cognitive functioning group. History of developmental abnormalities and persistent disorganization rather than diagnosis are significant predictors of the subgroup of individuals with global cognitive impairment in the schizophrenia-bipolar disorder continuum.
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    A comparative meta-analysis of peripheral 8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) levels across mood episodes in bipolar disorder
    (Elsevier Ltd, 2023) Çeli̇k, H. E. A.; Tuna, G.; Küçükgöncü, S.; N/A; Ceylan, Deniz; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 137755
    Objective: Oxidative DNA damage has been associated with the pathophysiology of bipolar disorder (BD) as one of the common pathways between increased medical comorbidity and premature aging in BD. Previous evidence shows increased levels of oxidatively induced DNA damage markers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) or its tautomer 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), in patients with BD in comparison to healthy individuals. With the current research, we aim to analyze data on peripheral (blood or urine) 8-OHdG/8-oxo-dG levels across mood states of BD using a meta-analytical approach. Method: A literature search was conducted using the databases PubMed, Scopus, and Web of Science to identify eligible studies (January 1989 to July 2022). Relevant studies were systematically reviewed; a random-effects meta-analysis and a meta-regression analysis were conducted. Results: The current meta-analysis included 12 studies consisting of 808 BD patients (390 in euthymia, 156 in mania, 137 in depression, 16 in mixed episode, 109 not specified) and 563 healthy controls. BD patients that were currently depressed had significantly higher levels of 8-OHdG/8-oxo-dG than healthy controls, while euthymic or manic patients did not differ from healthy controls. A meta-regression analysis showed sex distribution (being female) and older age to be significantly related to increased 8-OHdG/8-oxo-dG levels. Conclusion: Our findings suggest that 8-OHdG/8-oxo-dG may be a state-related marker of depression in BD and may be affected by older age and female gender.
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    Profile of young psychiatrists: a cross-sectional survey study from Turkey
    (ANP Publishing, 2021) Kılınçel, Oğuzhan; Erzin, Gamze; Kılınçel, Şenay; Şenol, Sevin Hun; Acar, Murat; Gürcan, Ahmet; Capraz, Necip; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
    Objective: In this study, it was aimed to discuss the problems and working conditions of Early Career Psychiatrist (ECP) in the light of the literature Method: ECPs (in the first five years of their residency or under forty years of age) were included in the study via e-mail. An online questionnaire structured by the researchers was applied to all participants. The first 7 of the questionnaire questions are related to socio-demographic characteristics, and they were asked about age, gender, city of residence, year of profession, state service obligation, the hospital where he worked, the institution he specialized in. In the continuation of the questionnaire, a total of 24 questions were asked about the clinical and practical applications of psychiatry, education, career and working environment. Results: A total of 245 ECPs, 69.8% female and 30.2% male, aged between 27 and 41 years were included in the study. The average age of the participants in the study was 33.59 ± 2.80 years. As a city, the most frequent (17.1%) attendance was from Istanbul. 71% of them had completed their compulsory service. The institution worked with was reported as the most frequently (39.2%) state hospital affiliated to the Ministry of Health. In our study, it was found that 65.7% of ECPs were subjected to violence in the working environment and 83.9% of those exposed to violence were exposed to verbal violence. Discussion: Both legal and institutional arrangements need to be made in order to improve the working conditions of ECPs, to prevent violence, to feel safe in the working environment and to increase the level of satisfaction. In addition, there is a need to increase the educational opportunities of ECPs after their specialization and to encourage scientific research.
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    Use of smartphone applications in the follow-up of individuals with bipolar disorder: psychiatrists' opinions and concerns
    (Wiley, 2022) Gurcan, Ahmet; Celik, Hidayet Ece; Alici, Yasemin Hosgoren; Bagcaz, Arda; Ercis, Mete; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
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    Mobile technology use and smartphone application interest in patients with bipolar disorder
    (Elsevier, 2021) Ozel, F.; Verim, B.; Kalayci, I.; Ekici, M. Yildirim; Ozerdem, A.; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755
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