Researcher:
Çelebi, Özlem

Profile Picture
ORCID

Job Title

Doctor

First Name

Özlem

Last Name

Çelebi

Name

Name Variants

Çelebi, Özlem

Email Address

Birth Date

Filters

2020 - 20223

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.ffb5b925-c592-42ed-afa4-8fb7d446fde2

Search Results

Now showing 1 - 3 of 3
  • Placeholder
    PublicationMetadata only
    The clinical use of impulse oscillometry in neuromuscular diseases
    (W. B. Saunders, 2022) Bayraktaroglu, Mesut; N/A; İliaz, Sinem; Yunisova, Gulshan; Çakmak, Özgür Öztop; Çelebi, Özlem; Buluş, Eser; Duman, Arda; Oflazer, Piraye; Doktor; Doktor; Faculty Member; Doktor; Doktor; Doktor; Faculty Member; N/A; N/A; School of Medicine; N/A; N/A; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; 299358; N/A; N/A; N/A; N/A
    Background: The patients with neuromuscular diseases (NMD) are very fragile and it is hard to evaluate respiratory involvement of the primary disease in this group. Therefore, our study aimed to reveal the relationship between pulmonary function tests (PFT) and impulse oscillometry (IOS) and their correlation with respiratory clinical findings in NMD. Material and methods: A total of 86 consecutive patients with NMD were included. The clinical findings of respiratory involvement, PFT, and IOS results of the patients were analyzed. Results: Forty patients out of 86 were female. There were 29 patients with amyotrophic lateral sclerosis, four patients with myasthenia gravis, and 53 patients with muscular dystrophies/myopathies. According to the PFT results, 47 patients had restrictive PFT. However, there was no difference in IOS parameters when we compared the patients according to restrictions in PFT. A positive correlation was found with FVC %pred and X-5. PEF % pred values were positively correlated with X-10, X-15, and X-20, and negatively correlated with A(X) and R5-20. The patients with worse swallowing capability had increased R-rs levels, and more negative X-rs levels. The shortness of breath led to lower FEV1 %pred., higher R-5, A(X) and R5-20, and also more negative X-10, X-15, and X-35. Conclusion: Clinically reported dysphagia, a decreased capability of coughing, and shortness of breath in patients with NMD make R-rs increase in general, but X-rs parameters, which mainly express rib cage elasticity, turn more negative. In patients with NMD, IOS monitoring may help in evaluating the regression in respiratory functions, however, future studies are needed to understand more.
  • Thumbnail Image
    PublicationOpen Access
    Is persistent post-COVID headache associated with protein-protein interactions between antibodies against viral spike protein and CGRP receptor?: a case report
    (Frontiers, 2022) Department of Chemical and Biological Engineering; N/A; Keskin, Özlem; Gürsoy, Attila; Özkan, Esra; Çelebi, Özlem; Özdemir, Yasemin Gürsoy; Faculty Member; Researcher; Doctor; Department of Chemical and Biological Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; College of Engineering; Koç University Hospital; 26605; 8745; N/A; N/A; 170592
    Background: after the acute pandemic of coronavirus disease 2019 (COVID-19), a wide variety of symptoms are identified under the term post-COVID syndrome, such as persistent headache. Post-COVID headache can be presented in a broad spectrum like headache attributed to systemic infection, chronification of already existing primary headache, or long-lasting, and also late-onset new daily persistent headache. Still, little is known about the pathophysiology of post-COVID headache, but activation of the trigeminovascular system may be one of the players. Case report: here, we present a case with a severe, long-lasting post-COVID headache and its sudden cessation with calcitonin gene-related peptide (CGRP) monoclonal antibody treatment. Conclusion: in our previous protein mimicry study, we have pointed at mimicry of virus spike protein and CGRP receptors. This mechanism may enlighten the current, common, and yet unsolved post-COVID headache cases.
  • Thumbnail Image
    PublicationOpen Access
    Comparative analysis of cognitive profiles of Huntington’s and Parkinson’s diseases
    (Galenos Yayınevi, 2020) Çakmaklı, Gül Yalçın; Akpulat, Gamze Elif Genç; Saka, Esen; Elibol, Bülent; Çelebi, Özlem; Doctor; Koç University Hospital
    Objective: In this study, our aim is to define the cognitive profile specific to Huntington’s disease (HD) in comparison to Parkinson’s disease (PD) without any accompanying cognitive involvement and to search for its relationship with CAG repeat number. Materials and Methods: Demographic data and detailed cognitive test results of HD and PD patients were reviewed, analyzed retrospectively and were compared to results of healthy controls (HC). Cognitive test battery included minimental state examination (MMSE), Beck’s depression inventory, enhanced cued recall (ECR), semantic fluency, digit-span forwards and backwards, trail making part A (TMT A) and B, reciting months backwards, phonemic fluency, Stroop, clock drawing, Benton’s line orientation, Benton’s facial recognition and Hooper visual organization tests. Instrumental activities of daily living test (IADL) was given for evaluating independence of patients in daily life. The relationship between test results and CAG repeat number and CAP score (product of CAG repeat number and age) for HD were evaluated. Results: Age, disease duration and number of years of education were similar between HD and PD. All cognitive test results of HD group were significantly worse than those of HC. HD group also scored significantly worse than PD group in MMSE, ECR, semantic fluency, TMT A, reciting months backwards, phonemic fluency, Stroop 1-5, clock drawing, Hooper visual organization and Benton’s facial recognition tests. CAP score was significantly correlated with the results of Stroop part 3-4 and scores of IADL. Conclusion: This study showed that HD has a cognitive profile with certain particular features, which differentiates it from PD. We can also conclude that cognitive decline takes place earlier in the course of HD compared to PD and it is more severe. CAP score was found corelated with executive functions and ADL in HD, confirming that the severity of pathological involvement is directly related to the cognitive profile of patients as well as their life quality.