Research Project: Silisyum-Florosein Tabanlı Aktive Edilebilir Fotodinamik Terapi Ajanlarının Tasarımı, Sentezi ve Terapötik Etkilerinin İncelenmesi
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Contributors
Funders
ID
TB.00360
Authors
Kölemen, Safacan
Faculty Member
Publications
Balanced intersystem crossing in iodinated silicon-fluoresceins allows new class of red shifted theranostic agents
(American Chemical Society (ACS), 2021) Çetin, Sultan; Gündüz, Hande; Kölemen, Safacan; Elmazoğlu, Zübeyir; Karaman, Osman; Günbaş, Görkem; Department of Chemistry; Graduate School of Sciences and Engineering; KUBAM (Koç University Boron and Advanced Materials Application and Research Center); KUTEM (Koç University Tüpraş Energy Center); KUYTAM (Koç University Surface Science and Technology Center); Yes; College of Sciences; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.
