Research Project: Silisyum-Florosein Tabanlı Aktive Edilebilir Fotodinamik Terapi Ajanlarının Tasarımı, Sentezi ve Terapötik Etkilerinin İncelenmesi
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Contributors
Funders
ID
TB.00360
Authors
Kölemen, Safacan
Faculty Member
Publications
Balanced intersystem crossing in iodinated silicon-fluoresceins allows new class of red shifted theranostic agents
(American Chemical Society (ACS), 2021)
Elmazoğlu, Zübeyir
Karaman, Osman
Günbaş, Görkem
Department of Chemistry
Graduate School of Sciences and Engineering
Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.