Research Project: Robotik ve Torakoskopik Akciğer Rezeksiyonlarının Postoperatif Inflamasyon Belirteçleri ve Stres
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Contributors
Funders
ID
TB.00386
Authors
Erus, Suat
Faculty Member
Publications
Immune profiling after minimally invasive lobectomy
(Oxford University Press (OUP), 2020) Albayrak, Özgür; Erus, Suat; İncir, Said; Öztürk, Ayşe Bilge; Tanju, Serhan; Yavuz, Ömer; Dilege, Şükrü; Kapdağlı, Murat Hüseyin; Cesur, Ekin Ezgi; KUTTAM (Koç University Research Center for Translational Medicine); KUH (Koç University Hospital); School of Medicine; Yes; KUH (KOÇ UNIVERSITY HOSPITAL); Research Center; SCHOOL OF MEDICINE
Objectives: Whether acute phase and immune responses are minimally affected following minimally invasive lung surgery needs further investigation. We performed a pilot study to evaluate the immune profile of patients who underwent video-assisted thoracoscopic surgery or robot-assisted thoracic surgery lobectomies for the treatment of suspicious or known stage I non-small-cell lung cancer. Methods: blood samples were taken preoperatively and 3 and 24 h postoperatively were analysed for C-reactive protein, glucose, cortisol, tumour necrosis factor alpha (TNF-α), interleukin 8 (IL-8) and interleukin 10 (IL-10) levels. TNF-α, IL-8 and IL-10 were also measured in lung tissues. T (CD4, CD8), B (CD19) and natural killer (CD56, CD16) cell counts and natural killer cell functions were analysed using a flow cytometry-based assay before and after surgery. Results: minimally invasive surgery (robot-assisted thoracic surgery + video-assisted thoracoscopic surgery) significantly decreased IL-10 (P = 0.016) levels after surgery. No significant differences were detected in TNF-α (P = 0.48) and IL-8 (P = 0.15) levels before and after surgery. C-reactive protein (P < 0.001), cortisol (P < 0.001) and glucose levels (P < 0.001) increased significantly after surgery. Lymphocyte, total T cell, CD3+CD4+ and CD3+CD8+ CD16+CD56+ cell counts were significantly lower on postoperative day 1. Conclusion: there seems to be a dynamic balance between pro- and anti-inflammatory cytokines and immune cells following minimally invasive lobectomy.
