Publication: The efficacy of lacosamide in children with drug-resistant focal epilepsy
Program
KU-Authors
KU Authors
Co-Authors
Yıldırım, Canan
Advisor
Publication Date
2021
Language
English
Type
Journal Article
Journal Title
Journal ISSN
Volume Title
Abstract
Introduction: This study aimed to assess the efficacy, tolerability and adverse effects of Lacosamide (LCM) in children with refractory focal epilepsy. Methods: Children aged younger than 16 years with drug-resistant focal epilepsy were enrolled. The medical records and seizure diaries that were evaluated every three months were reviewed. Response to LCM was defined as ≥50% reduction in seizure frequency. Results: Twenty-five children with drug-resistant focal epilepsy received LCM as add-on therapy. The mean duration of epilepsy was 5.2 years and the mean age at LCM initiation was 8 years. The rate of response to LCM treatment in the 3th, 6th and 9th months were 44%, 64%, 76%, respectively. At the end of 12 months, the response rate was 84% and 16% of the patients were seizure free. Four patients had adverse effects; three patients were discontinued LCM and one improved after decreasing the dose of the drug. Discussion and Conclusion: LCM is an effective add-on antiepileptic drug for children with refractory focal epilepsy. It diminishes the frequency of seizures over time. It is well tolerated and a promising option in these patients.
Description
Source:
Haydarpaşa Numune Medical Journal
Publisher:
Haydarpaşa Numune Training and Research Hospital
Keywords:
Subject
Children, Epilepsy, Çocuklar, Epilepsi