Publication: Is there a comparable Mp-MRI for incidental prostate uptake on 18 F-FDG PET/CT?
dc.contributor.coauthor | Şam Özdemir M., Kaya N., Savun M., Keskin E.T., Arslan F.Z., Budak B., Omak Ö., Yardımcı A.H., Özdemir H. | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.kuauthor | Yüzkan, Sabahattin | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.date.accessioned | 2025-03-06T21:01:34Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Purpose: Although 18 F-FDG-PET/CT is helpful in defining many types of cancer, localized prostate cancer should not be treated with this technique. This study describes the use of multi-parametric MRI (mpMRI) to characterize incidental 18 F-FDG uptake in the prostate. Methods and Materials: While 18 F-FDG-PET/CT is useful for characterizing a variety of cancers, it is not advised for prostate cancer that is localized. This work investigates the use of mpMRI to describe incidental 18 F-FDG uptake in the prostate.mpMRI included T2-weighted (T2W), dynamic contrast enhancement (DCE), and apparent diffusion coefficient (ADC) sequences. Patients were classified according to PI-RADS (Prostate Imaging Reporting and Data System) version 2.1 by an experienced uroradiologist, and 18 F-FDG-PET was evaluated to determine whether the area of involvement on CT had a counterpart in mpMRI. A biopsy was performed on 30 of the 92 patients. These patients’ maximum standardized uptake values (SUVmax) 6 < and ≥ 6, PS(PSA) density 0.15 < and ≥ 0.15, PSA level, uptake pattern (focal involvement/diffuse involvement), and PI-RADS scores were compared. P <.05 was considered statistically significant. Logistic regression was used to analyze PI-RADS score groups age, PSA, PSA density and SUVmax. Results: In the study, 92 patients with incidental 18 F-FDG-PET/CT prostate uptake were examined. Median age was 66, PSA median was 3.6 ng/ml (range: 0-3198 ng/ml). Notably, in 70.6% of cases, PET/CT uptake didn’t correlate with mp-MRI findings. Among PI-RADS 3-4-5 patients (29.3%), there was a correlation. Biopsies in 30 patients revealed 43.3% benign, 56.7% malignant. Significant differences between benign and malignant cases were observed in PSA density, PI-RADS scores, and PSA levels (p <.05), while SUVmax and uptake pattern were not significant. In multivariate logistic regression analysis, PI-RADS score groups were found to be independent risk factors for predicting malignancy. Conclusions: Our study showed that incidental 18 F-FDG-PET/CT prostate uptake was detected and that high PSA density values, PI-RADS scores, and PSA values, such as in routine patients, and not PET-CT findings such as SUVmax and uptake pattern, were more predictive of malignancy. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.identifier.doi | 10.1186/s12957-024-03578-0 | |
dc.identifier.issn | 1477-7819 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85212785395 | |
dc.identifier.uri | https://doi.org/10.1186/s12957-024-03578-0 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/28002 | |
dc.identifier.wos | 1381661000002 | |
dc.keywords | 18F-FDG PET-CT | |
dc.keywords | Multi-parametric MRI | |
dc.keywords | Prostate cancer | |
dc.keywords | Incidental prostate 18F-FDG uptake | |
dc.language.iso | eng | |
dc.publisher | BioMed Central Ltd | |
dc.relation.ispartof | World Journal of Surgical Oncology | |
dc.subject | Oncology | |
dc.subject | Urology and nephrology | |
dc.title | Is there a comparable Mp-MRI for incidental prostate uptake on 18 F-FDG PET/CT? | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Yüzkan, Sabahattin | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
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