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Microneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling

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dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUAR (KU Arçelik Research Center for Creative Industries)
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUIS AI (Koç University & İş Bank Artificial Intelligence Center)
dc.contributor.facultymemberYes
dc.contributor.kuauthorAhmadpour, Abdollah
dc.contributor.kuauthorTaşoğlu, Savaş
dc.contributor.kuauthorSarabi, Misagh Rezapour
dc.contributor.kuauthorMuradoğlu, Metin
dc.contributor.kuauthorUral, Berk
dc.contributor.kuauthorİşgör, Pelin Kübra
dc.contributor.kuauthorEren, Büşra Nimet
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-01-19T10:27:45Z
dc.date.issued2023
dc.description.abstractMicroneedle arrays are patches of needles at micro- and nano-scale, which are competent and versatile technologies that have been merged with microfluidic systems to construct more capable devices for biomedical applications, such as drug delivery, wound healing, biosensing, and sampling body fluids. In this paper, several designs and applications are reviewed. In addition, modeling approaches used in microneedle designs for fluid flow and mass transfer are discussed, and the challenges are highlighted.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccesshybrid
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipS.T. acknowledges the Tubitak 2232 International Fellowship for Outstanding Researchers Award (No. 118C391), the Alexander von Humboldt Research Fellowship for Experienced Researchers, the Marie Sklodowska-Curie Individual Fellowship (No. 101003361), and the Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership Award (No. 120N019) for financial support of this research. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the TUEBITAK. This work was partially supported by Science Academy's Young Scientist Awards Program (BAGEP), Outstanding Young Scientists Awards (GEBIP), and Bilim Kahramanlari Dernegi-The Young Scientist Award. This study was conducted using the service and infrastructure of Koc University Translational Medicine Research Center (KUTTAM). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
dc.description.sponsorshipAlexander von Humboldt Foundation
dc.description.sponsorshipMarie Curie Actions
dc.description.sponsorshipRoyal Academy Newton-Katip Celebi Transforming Systems Through Partnership Award
dc.description.sponsorshipScience Academy's Young Scientist Awards Program (BAGEP)
dc.description.sponsorshipOutstanding Young Scientists Awards (GEBIP)
dc.description.sponsorshipBilim Kahramanlari Dernegi-The Young Scientist Award
dc.description.studentonlypublicationNo
dc.description.studentpublicationYes
dc.description.versionN/A
dc.identifier.WoSQuartileQ3
dc.identifier.doi10.1063/5.0121578
dc.identifier.eissn1932-1058
dc.identifier.embargoN/A
dc.identifier.grantno118C391
dc.identifier.grantno101003361
dc.identifier.grantno120N019
dc.identifier.issue2
dc.identifier.pubmed37153866
dc.identifier.scopus2-s2.0-85158869482
dc.identifier.urihttps://doi.org/10.1063/5.0121578
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25598
dc.identifier.volume17
dc.identifier.wos000967535800001
dc.keywordsDrug delivery
dc.keywordsFlow of fluids
dc.keywordsFluidic devices
dc.keywordsMass transfer
dc.keywordsMedical applications
dc.keywordsMicrofluidics
dc.keywordsNanotechnology
dc.keywordsNeedles
dc.language.isoeng
dc.publisherAmerican Institute of Physics Inc.
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofBiomicrofluidics
dc.relation.openaccessN/A
dc.relation.projectGlioma on a chip: Probing Glioma Cell Invasion and Gliomagenesis on a Multiplexed Chip
dc.relation.project3D Spatiotemporal Control of Neurons and Disease Modeling
dc.relation.projectSuriyeli Göçmenlerde Çoklu-İlaç-Dirençli Tüberküloz Hastalığının Tanısı İçin Ucuz Maliyetli Hasta Başı Kullanıma Uygun Cihaz Gelişimi ve Doğrulaması
dc.rightsN/A
dc.subjectBiochemical research methods
dc.subjectBiophysics
dc.subjectNanoscience and nanotechnology
dc.subjectPhysics
dc.titleMicroneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAhmadpour, Abdollah
local.contributor.kuauthorIşgör, Pelin Kübra
local.contributor.kuauthorUral, Berk
local.contributor.kuauthorEren, Büşra Nimet
local.contributor.kuauthorSarabi, Misagh Rezapour
local.contributor.kuauthorMuradoğlu, Metin
local.contributor.kuauthorTaşoğlu, Savaş
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