Publication:
Adjuvant chemoradiotherapy after D2 resection in gastric cancer: a single-center observational study

dc.contributor.coauthorSaglam, Esra Kaytan
dc.contributor.coauthorYucel, Serap
dc.contributor.coauthorSaglam, Sezer
dc.contributor.coauthorAsoglu, Oktar
dc.contributor.coauthorYamaner, Sumer
dc.contributor.coauthorOral, Ethem N.
dc.contributor.coauthorKizir, Ahmet
dc.contributor.coauthorKapran, Yersu
dc.contributor.coauthorSakar, Burak
dc.contributor.coauthorAkyuz, Ali
dc.contributor.coauthorGulluoglu, Mine
dc.contributor.departmentN/A
dc.contributor.kuauthorBalık, Emre
dc.contributor.kuauthorBuğra, Dursun
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid18758
dc.contributor.yokid1758
dc.date.accessioned2024-11-09T23:05:57Z
dc.date.issued2015
dc.description.abstractPrevious studies demonstrated survival benefits in association with the addition of chemoradiotherapy after surgery in gastric cancer. This study aimed to examine the efficacy in terms of loco-regional control and survival and safety of 5-FU-based adjuvant chemoradiotherapy after D2 curative surgery. This study included 228 patients (81 female, 147 male) treated for gastric cancer with curative surgery plus adjuvant chemoradiotherapy. Majority of the patients underwent at least D2 lymph node resection. Median three cycles of fluorouracil chemotherapy were administered, and 45-Gy radiotherapy was delivered at 1.8 Gy/fraction concomitantly during the second cycle of chemotherapy. Local control, regional control, distant metastasis and overall survival rates were estimated. The median age of the patients was 54 years (range 25-74 years). The most common grade III toxicities were nausea (10 %) and neutropenia (9 %). During radiotherapy, grade IV local skin reaction occurred in one patient. Median duration of follow-up was 47 months. Local, regional and distant recurrence developed in 9 (4 %), 41 (18 %) and 45 (20 %) patients, respectively. Overall 5-year survival rate was 57.2 %, and disease-free 5-year survival rate was 53.8 %. Multivariate analysis identified less than 15 lymph node involvement as an independent predictor of better survival (p < 0.001). Concomitant 5-FU-based chemoradiotherapy seems to be an effective and tolerable adjuvant regimen on local control and survival in curatively resected node-positive stomach cancer, particularly when combined with D2 resection.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.issue2
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume141
dc.identifier.doi10.1007/s00432-014-1816-y
dc.identifier.eissn1432-1335
dc.identifier.issn0171-5216
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84921048200
dc.identifier.urihttp://dx.doi.org/10.1007/s00432-014-1816-y
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8881
dc.identifier.wos347828100018
dc.keywordsAdjuvant therapy
dc.keywordsChemoradiotherapy
dc.keywordsGastric cancer
dc.keywordsD2 resection
dc.languageEnglish
dc.publisherSpringer
dc.sourceJournal of Cancer Research and Clinical Oncology
dc.subjectOncology
dc.titleAdjuvant chemoradiotherapy after D2 resection in gastric cancer: a single-center observational study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-5751-1133
local.contributor.authorid0000-0003-0316-6818
local.contributor.kuauthorBalık, Emre
local.contributor.kuauthorBuğra, Dursun

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