Publication:
Taming oncogenic signaling at protein interfaces: challenges and opportunities

dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorCavga, Ayşe Derya
dc.contributor.kuauthorGürsoy, Attila
dc.contributor.kuauthorKarahan, Nilay
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T22:49:36Z
dc.date.issued2015
dc.description.abstractMany key cellular events determining the thin line between healthy and oncogenic behavior rely on the proper functioning of protein-protein interactions (PPIs). Alterations that affect the affinity of a protein-protein binding site may destabilize a desired healthy interaction, or stabilize an oncogenic interaction. The understanding that there are a few key hot-spot residues that are mainly responsible for the binding energy of an interaction greatly widened the prospects of targeting oncogenic protein-protein interfaces enabling the use of small ligands in addition to biological molecules such as peptides and antibodies. Taming oncogenic signaling requires a deep understanding of protein interactions and their networks. Traditional representation of PPIs in signaling pathways as nodes and edges falls short of expressing interaction specific modulation of signals. Structural networks, deciphering which sites on a protein structure are responsible for each of the many interactions it may carry out, help understanding specific oncogenic mutations on signaling. We describe the key features of PPIs and their targeting, together with the advantages of structural networks, and provide four case studies demonstrating different opportunities for the aim of modulating oncogenic interactions.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue20
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume15
dc.identifier.doi10.2174/1568026615666150519101956
dc.identifier.eissn1873-5294
dc.identifier.issn1568-0266
dc.identifier.scopus2-s2.0-84937120502
dc.identifier.urihttps://doi.org/10.2174/1568026615666150519101956
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6532
dc.identifier.wos357694200002
dc.keywordsDrug design
dc.keywordsHot-spots
dc.keywordsOncogenic Signaling
dc.keywordsProtein interaction networks
dc.keywordsProtein-protein interactions
dc.keywordsProtein-protein interface
dc.keywordsMutant P53
dc.keywordsHot-spots
dc.keywordsSmall molecules
dc.keywordsAntagonists induce
dc.keywordsBreast-cancer
dc.keywordsNetwork
dc.keywordsBinding
dc.keywordsPrediction
dc.keywordsInhibitor
dc.keywordsResidues
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Topics In Medicinal Chemistry
dc.subjectChemistry
dc.subjectMedicinal
dc.titleTaming oncogenic signaling at protein interfaces: challenges and opportunities
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorCavga, Ayşe Derya
local.contributor.kuauthorKarahan, Nilay
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorGürsoy, Attila
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2Department of Computer Engineering
local.publication.orgunit2Graduate School of Sciences and Engineering
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