Publication:
Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

dc.contributor.coauthorSmith, Emily R.
dc.contributor.coauthorOakley, Erin
dc.contributor.coauthorGrandner, Gargi Wable
dc.contributor.coauthorFerguson, Kacey
dc.contributor.coauthorFarooq, Fouzia
dc.contributor.coauthorAfshar, Yalda
dc.contributor.coauthorAhlberg, Mia
dc.contributor.coauthorAhmadzia, Homa
dc.contributor.coauthorAkelo, Victor
dc.contributor.coauthorAldrovandi, Grace
dc.contributor.coauthorBarr, Beth A. Tippett
dc.contributor.coauthorBevilacqua, Elisa
dc.contributor.coauthorBrandt, Justin S.
dc.contributor.coauthorBroutet, Nathalie
dc.contributor.coauthorBuhigas, Irene Fernandez
dc.contributor.coauthorCarrillo, Jorge
dc.contributor.coauthorClifton, Rebecca
dc.contributor.coauthorConry, Jeanne
dc.contributor.coauthorCosmi, Erich
dc.contributor.coauthorCrispi, Fatima
dc.contributor.coauthorCrovetto, Francesca
dc.contributor.coauthorDelgado-Lopez, Camille
dc.contributor.coauthorDivakar, Hema
dc.contributor.coauthorDriscoll, Amanda J.
dc.contributor.coauthorFavre, Guillaume
dc.contributor.coauthorFlaherman, Valerie J.
dc.contributor.coauthorGale, Chris
dc.contributor.coauthorGil, Maria M.
dc.contributor.coauthorGottlieb, Sami L.
dc.contributor.coauthorGratacos, Eduard
dc.contributor.coauthorHernandez, Olivia
dc.contributor.coauthorJones, Stephanie
dc.contributor.coauthorKhagayi, Sammy
dc.contributor.coauthorKnight, Marian
dc.contributor.coauthorKotloff, Karen
dc.contributor.coauthorLanzone, Antonio
dc.contributor.coauthorLe Doare, Kirsty
dc.contributor.coauthorLees, Christoph
dc.contributor.coauthorLitman, Ethan
dc.contributor.coauthorLokken, Erica M.
dc.contributor.coauthorLaurita Longo, Valentina
dc.contributor.coauthorMadhi, Shabir A.
dc.contributor.coauthorMagee, Laura A.
dc.contributor.coauthorMartinez-Portilla, Raigam Jafet
dc.contributor.coauthorMcClure, Elizabeth M.
dc.contributor.coauthorMetz, Tori D.
dc.contributor.coauthorMiller, Emily S.
dc.contributor.coauthorMoney, Deborah
dc.contributor.coauthorMoungmaithong, Sakita
dc.contributor.coauthorMullins, Edward
dc.contributor.coauthorNachega, Jean B.
dc.contributor.coauthorNunes, Marta C.
dc.contributor.coauthorOnyango, Dickens
dc.contributor.coauthorPanchaud, Alice
dc.contributor.coauthorPoon, Liona C.
dc.contributor.coauthorRaiten, Daniel
dc.contributor.coauthorRegan, Lesley
dc.contributor.coauthorRukundo, Gordon
dc.contributor.coauthorSahota, Daljit
dc.contributor.coauthorSakowicz, Allie
dc.contributor.coauthorSanin-Blair, Jose
dc.contributor.coauthorSoderling, Jonas
dc.contributor.coauthorStephansson, Olof
dc.contributor.coauthorTemmerman, Marleen
dc.contributor.coauthorThorson, Anna
dc.contributor.coauthorTolosa, Jorge E.
dc.contributor.coauthorTownson, Julia
dc.contributor.coauthorValencia-Prado, Miguel
dc.contributor.coauthorVisentin, Silvia
dc.contributor.coauthorvon Dadelszen, Peter
dc.contributor.coauthorWaldorf, Kristina Adams
dc.contributor.coauthorWhitehead, Clare
dc.contributor.coauthorYassa, Murat
dc.contributor.coauthorTielsch, Jim M.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKalafat, Erkan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:50:36Z
dc.date.issued2023
dc.description.abstractIntroductionDespite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies. MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale. ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection-as compared with uninfected pregnant women-were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias. ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipBill & Melinda Gates Foundation [INV- 022057] Funded by the Bill & Melinda Gates Foundation grant to ERS (INV- 022057).
dc.description.volume8
dc.identifier.doi10.1136/bmjgh-2022-009495
dc.identifier.issn2059-7908
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85146924226
dc.identifier.urihttps://doi.org/10.1136/bmjgh-2022-009495
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6690
dc.identifier.wos926228300001
dc.keywordsCOVID-19
dc.keywordsMaternal health
dc.keywordsEpidemiology
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofBMJ Global Health
dc.subjectPubli
dc.subjectOccupational health
dc.titleAdverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKalafat, Erkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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