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Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson's disease

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dc.contributor.coauthorMunoz-Delgado, Laura
dc.contributor.coauthorWilliams-Gray, Caroline H.
dc.contributor.coauthorGarraux, Gaetan
dc.contributor.coauthorClemente, Diego
dc.contributor.coauthorCakmak, Ozgur Oztop
dc.contributor.coauthorGreenland, Julia C.
dc.contributor.coauthorFigueira, Ines
dc.contributor.coauthorMachin-Diaz, Isabel
dc.contributor.coauthorPirovano, Elenamaria
dc.contributor.coauthordi Flora, Alessia
dc.contributor.coauthorTournerie, Clotilde
dc.contributor.coauthorPapoutsopoulou, Stamatia
dc.contributor.coauthorErtan, Sibel
dc.contributor.coauthorMir, Pablo
dc.contributor.coauthorComi, Cristoforo
dc.date.accessioned2025-12-31T08:23:43Z
dc.date.available2025-12-31
dc.date.issued2025
dc.description.abstractGrowing evidence supports the importance of immune processes in Parkinson's disease (PD). However, there is a need to improve the quality of observational clinical studies investigating the role of immunity in PD. In this context, an expert panel from the COST Action IMMUPARKNET (CA21117) aimed to develop guidance recommendations for conducting optimal immune profiling in PD. Firstly, criteria for inclusion and exclusion of participants, clinical data collection and participant stratification have been considered. Secondly, brain imaging of neuroinflammation has been reviewed. Finally, this review discusses sample collection, handling and storage of biological samples. In conclusion, this document aims to guide the scientific community in the optimal design of immune profiling studies in PD, so that we can generate robust and reliable data to advance our knowledge in this field.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyPubMed
dc.description.openaccessgold
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipCOST Action [CA21117]; COST (European Cooperation in Science and Technology); Instituto de Salud Carlos III [JR23/00016, PI18/00357, PI21/00302, PI24/00447]; Consejeria de Salud y Consumo de la Junta de Andalucia [NEU-0005-2022]; NIHR Cambridge Biomedical Research Centre [NIHR203312]; Cambridge Centre for Parkinson-Plus; UKRI Medical Research Council [MR/W029235/1]; Cure Parkinson's; Parkinson's UK; Rosetrees Trust; Ecupharma; Fonds Rahier, University of Liege and Fonds de la Recherche Scientifique (F.R.S.-FNRS) de Belgique; Bial; Novartis; European Union; CIBERNED [CB22/05/00016]; European Union Next Generation funds; EMD Serono RD Agreement; ERC [804229, PeX-2022.02127.PTDC]; R&D unit iNOVA4Health [LISBOA-01-0145-FEDER-007344, UIDB/04462/2020]; LS4FUTURE Associated Laboratory [LA/P/0087/2020]; Spanish Ministry of Science and Innovation [RTC2019-007150-1]; Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (ISCIII-FEDER) [PI16/01575, PI18/01898, PI19/01576, PI20/00613, PI21/01875, PI22/01704, PI23/00512]; Consejeria de Economia, Innovacion, Ciencia y Empleo de la Junta de Andalucia [CVI-02526, CTS-7685]; Consejeria de Salud y Bienestar Social de la Junta de Andalucia [PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019]; Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades de la Junta de Andalucia [PY20_00896]; AGING PROJECT-Department of Excellence-Universita del Piemonte Orientale
dc.identifier.doi10.1038/s41531-025-01146-1
dc.identifier.eissn2373-8057
dc.identifier.embargoNo
dc.identifier.issue1
dc.identifier.pubmed41115922
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.1038/s41531-025-01146-1
dc.identifier.urihttps://hdl.handle.net/20.500.14288/31748
dc.identifier.volume11
dc.identifier.wos001596233800002
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofNPJ PARKINSONS DISEASE
dc.relation.openaccessNo
dc.rightsCopyrighted
dc.subjectNeurosciences & Neurology
dc.titleRecommendations for clinical study protocols for immune and inflammatory profiling in Parkinson's disease
dc.typeReview
dspace.entity.typePublication

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