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Disposable paper-based microfluidics for fertility testing

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dc.contributor.coauthorAlseed, M. Munzer
dc.contributor.coauthorMathyk, Begüm Aydoğan
dc.contributor.coauthorHalıcıgil, Cihan
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorTaşoğlu, Savaş
dc.contributor.kuauthorSarabi, Misagh Rezapour
dc.contributor.kuauthorYığcı, Defne
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.kuprofileFaculty Member
dc.contributor.otherDepartment of Mechanical Engineering
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.researchcenterKU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR)
dc.contributor.researchcenterKoç Üniversitesi İş Bankası Yapay Zeka Uygulama ve Araştırma Merkezi (KUIS AI)/ Koç University İş Bank Artificial Intelligence Center (KUIS AI)
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGraduate School of Sciences and Engineering
dc.contributor.yokid291971
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T13:07:34Z
dc.date.issued2022
dc.description.abstractFifteen percent of couples of reproductive age suffer frominfertility globally and the burden of infertility disproportionately impacts residents of developing countries. Assisted reproductive technologies (ARTs), including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), have been successful in overcoming various reasons for infertility including borderline and severe male factor infertility which consists of 20%-30% of all infertile cases. Approximately half of male infertility cases stem from suboptimal sperm parameters. Therefore, healthy/normal sperm enrichment and sorting remains crucial in advancing reproductive medicine. Microfluidic technologies have emerged as promising tools to develop in- home rapid fertility tests and point-of-care (POC) diagnostic tools. Here, we review advancements in fabrication methods for paper-based-microfluidic devices and their emerging fertility testing applications assessing sperm concentration, sperm motility, sperm DNA analysis, and other sperm functionalities, and provide a glimpse into future directions for paper-based fertility microfluidic systems.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue9
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorship2232 International Fellowship for Outstanding Researchers Award
dc.description.sponsorshipEuropean Union (EU)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipMarie Sklodowska-Curie Individual Fellowship
dc.description.sponsorshipRoyal Academy Newton-Katip Çelebi Transforming Systems Through Partnership Award
dc.description.sponsorshipAlexander von Humboldt Research Fellowship for Experienced Researchers
dc.description.sponsorshipScience Academy Young Scientist Awards Program (BAGEP)
dc.description.sponsorshipOutstanding Young Scientists Awards (GEBİP)
dc.description.sponsorshipBilim Kahramanlari Dernegi Young Scientist Award
dc.description.versionPublisher version
dc.description.volume25
dc.formatpdf
dc.identifier.doi10.1016/j.isci.2022.104986
dc.identifier.eissn2589-0042
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR04068
dc.identifier.linkhttps://doi.org/10.1016/j.isci.2022.104986
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85137304961
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2611
dc.identifier.wos880099100010
dc.keywordsScience and technology
dc.languageEnglish
dc.publisherElsevier
dc.relation.grantno118C391
dc.relation.grantno101003361
dc.relation.grantno101003361
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10950
dc.sourceiScience
dc.subjectMultidisciplinary sciences
dc.titleDisposable paper-based microfluidics for fertility testing
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0003-4604-217X
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.kuauthorTaşoğlu, Savaş
local.contributor.kuauthorSarabi, Misagh Rezapour
local.contributor.kuauthorYığcı, Defne
local.contributor.kuauthorAta, Mustafa Barış
relation.isOrgUnitOfPublicationba2836f3-206d-4724-918c-f598f0086a36
relation.isOrgUnitOfPublication.latestForDiscoveryba2836f3-206d-4724-918c-f598f0086a36

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