Publication: Does dehydroepiandrosterone have any benefit in fertility treatment?
Program
KU-Authors
KU Authors
Co-Authors
Yakın, Kayhan
Publication Date
Language
Type
Embargo Status
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Abstract
Purpose of Review: Androgens and particularly dehydroepiandrosterone (DHEA) have been advocated as adjuncts to ovarian stimulation in women with diminished ovarian reserve. Given the limited number of options in these women it is understandable that both physicians and patients resort to treatments that are not evidence based. Recent Findings: DHEA is such an adjunct and has been recently used extensively in women responding poorly to gonadotropins and women of advanced age seeking treatment with assisted reproductive techniques. Although androgens may be biologically plausible, current evidence is not sufficient to prove their effectiveness. Summary: Until well designed studies show a beneficial effect of DHEA supplementation in women with a diminished ovarian reserve, its widespread use should be discouraged. The patients should be counseled regarding the experimental nature of such a treatment.
Source
Publisher
Lippincott Williams and Wilkins (LWW)
Subject
Obstetrics, Gynecology
Citation
Has Part
Source
Current Opinion in Obstetrics and Gynecology
Book Series Title
Edition
DOI
10.1097/GCO.0b013e32835175c3