Publication:
Diffusion tensor ımaging parameters in children with acute hyperammonemic encephalopathy due to urea cycle enzyme defects and organic acidemia

Placeholder

Departments

Organizational Unit

School / College / Institute

Organizational Unit
SCHOOL OF MEDICINE
Upper Org Unit

Program

KU-Authors

KU Authors

Co-Authors

Kurtcan, Serpil
Alkan, Alpay
Toprak, Hüseyin
Tüzün, Ümit
Aralaşmak, Ayşe

Publication Date

Language

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Background: Prolonged hyperammonemia, as a result of its toxic effect, may cause irreversible damage in the central nervous system. Objective: We aimed to determine whether there were DTI changes in brains of pediatric subjects with acute hyperammonemic encephalopathy due to Urea Cycle Defects (UCD) and Organic Acidemia (OA). Methods: Eleven children with acute hyperammonemic encephalopathy (UCD, n=5; OA, n=6) and 9 controls were included in study. Routine MRI and diffusion-weighted images at b= 0 s mm(-2) and b= 1000 s mm(-2) were applied. Then, DTI sequence was performed. ADC and FA comparisons of all subjects were performed by nonparametric tests (the Mann-Whitney test, Kruskal-Wallis test). Results: The mean ADCs of the perirolandic cortex (p=0.037), cerebellar white matter (p=0.006), cingulum (p=0.017), temporal and frontal periventricular white matter (p=0.030) (p=0.020), and parietal subcortical white matter (p=0.037) were statistically higher in all subjects than controls. FAs of nucleus caudatus (p=0.034), putamen (p=0.004), perirolandic cortex (p=0.026), corpus callosum genu (p=0.031), temporal periventricular white matter (p=0.003), and occipital periventricular and subcortical white matter (p=0.045, p=0.026) were lower in both subjects with UCD and OA than controls. FAs of splenium of the corpus callosum (p=0.012) in subjects with UCD were lower compared to subjects with OA and the control group. FAs of hippocampus and parietal subcortical white matter in subjects with OA were lower compared to subjects with UCD and the control group (p=0.03 1). Conclusion: On DTI, both UCDs and OAs demonstrated similar DTI changes in same regions compared to controls. These changes in ADC and FA values in both conditions may indicate microstructural damage. In this context, DTI findings may contribute to a better understanding of the underlying pathophysiology of disease.

Source

Publisher

Bentham Science Publ Ltd

Subject

Radiology, Nuclear medicine, Medical imaging

Citation

Has Part

Source

Current Medical Imaging Reviews

Book Series Title

Edition

DOI

10.2174/1573405613666170717101901

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads

View PlumX Details