Publication:
Basic physiology of the blood-brain barrier in health and disease: a brief overview

dc.contributor.coauthorN/A
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAhıshalı, Bülent
dc.contributor.kuauthorKaya, Mehmet
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:08:11Z
dc.date.issued2021
dc.description.abstractThe blood-brain barrier (BBB), a dynamic interface between blood and brain constituted mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially harmful blood-sourced substances and cells into the brain, however, many therapeutically active agents concurrently cannot gain access into the brain at effective doses in the presence of an intact barrier. On the other hand, breakdown of BBB integrity may involve in the pathogenesis of various neurodegenerative diseases. Besides, certain diseases/disorders such as Alzheimer's disease, hypertension, and epilepsy are associated with varying degrees of BBB disruption. In this review, we aim to highlight the current knowledge on the cellular and molecular composition of the BBB with special emphasis on the major transport pathways across the barrier type endothelial cells. We further provide a discussion on the innovative brain drug delivery strategies in which the obstacle formed by BBB interferes with effective pharmacological treatment of neurodegenerative diseases/disorders.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipPresidency of Turkey, Presidency of Strategy and Budget the authors gratefully acknowledge use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTaM), funded by the Presidency of Turkey, Presidency of Strategy and Budget. the content is solely the responsibility of the authors and does not necessarily represent the official views of the Presidency of Strategy and Budget. the authors would also like to thank Ph.D. student Uur akcan for his contribution to the preparation of schematic illustrations of the manuscript.
dc.description.volume9
dc.identifier.doi10.1080/21688370.2020.1840913
dc.identifier.issn2168-8370
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85096101602
dc.identifier.urihttps://doi.org/10.1080/21688370.2020.1840913
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16911
dc.identifier.wos680860400001
dc.keywordsBlood-brain barrier
dc.keywordsEndothelial cells
dc.keywordsTight junctions
dc.keywordsParacellular permeability
dc.keywordsTranscellular permeability
dc.language.isoeng
dc.publisherTaylor and Francis inc
dc.relation.ispartofTissue Barriers
dc.subjectMedicine
dc.subjectResearch and experimental medicine
dc.titleBasic physiology of the blood-brain barrier in health and disease: a brief overview
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKaya, Mehmet
local.contributor.kuauthorAhıshalı, Bülent
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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