Publication:
Frameless hypofractionated gamma knife radiosurgery for residual or recurrent craniopharyngioma

dc.contributor.coauthorEssibayi, Muhammed Amir
dc.contributor.coauthorAskeroglu, Mehmet Orbay
dc.contributor.coauthorBudak, Mustafa
dc.contributor.coauthorKarakose, Fatih
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAskeroğlu, Mehmet Orbay
dc.contributor.kuauthorPeker, Selçuk
dc.contributor.kuauthorBudak, Mustafa
dc.contributor.kuauthorSamancı, Mustafa Yavuz
dc.contributor.kuauthorKaraköse, Fatih
dc.contributor.kuauthorEssibayi, Muhammed Amir
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:34:07Z
dc.date.issued2023
dc.description.abstractBACKGROUND:The management of craniopharyngiomas is challenging, usually requiring multidisciplinary care. Gamma Knife radiosurgery (GKRS) is an essential technique for residual/recurrent craniopharyngiomas.OBJECTIVE:To evaluate the efficacy of frameless hypofractionated GKRS (hfGKRS) for craniopharyngioma and factors which affect tumor control and complications.METHODS:This retrospective study involved 24 patients managed with hfGKRS. Clinical and radiological data, tumor characteristics, and procedural details were analyzed.RESULTS:There were 15 (62.5%) female patients. The median age was 38.5 years (range, 3-66 years). The mean tumor volume was 2.4 (1.93) cm(3), with a mean solid volume of 1.6 (1.75) cm(3). The median marginal dose was 20 Gy (range, 18-25 Gy) delivered in a median of 5 fractions (range, 3-5). During a median radiological follow-up of 23.5 months (range, 12-50 months), tumor progression was noted in 5 (20.8%) patients. The 2-year and 4-year progression-free survival were 81.8% and 61.4%, respectively. No deaths were identified at a median clinical follow-up of 31.3 months (range, 12-54 months). Visual deficits attributable to progression were noted in 3 (12.5%) patients with pre-GKRS visual field defects. An additional 4 (16.7%) patients with pre-GKRS visual deficit developed new minor visual field defects. Four (16.7%) patients showed improvement of vision after GKRS. There were no new-onset post-GKRS hormonal deficits.CONCLUSION:The management of craniopharyngioma requires a multidisciplinary approach, and irradiation represents effective treatment option for residual/recurrent tumors after surgery. To the best of our knowledge, this is the first study that addresses the efficacy of frameless hfGKRS in managing craniopharyngiomas over sufficient follow-up.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume93
dc.identifier.doi10.1227/neu.0000000000002382
dc.identifier.eissn1524-4040
dc.identifier.issn0148-396X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85163452211
dc.identifier.urihttps://doi.org/10.1227/neu.0000000000002382
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26732
dc.identifier.wos1010656700022
dc.keywordsCraniopharyngioma
dc.keywordsFrameless
dc.keywordsHypofractionated
dc.keywordsGamma Knife
dc.keywordsManagement
dc.keywordsRadiosurgery
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofNeurosurgery
dc.subjectMedicine
dc.titleFrameless hypofractionated gamma knife radiosurgery for residual or recurrent craniopharyngioma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorPeker, Selçuk
local.contributor.kuauthorSamancı, Mustafa Yavuz
local.contributor.kuauthorAskeroğlu, Mehmet Orbay
local.contributor.kuauthorBudak, Mustafa
local.contributor.kuauthorKaraköse, Fatih
local.contributor.kuauthorEssibayi, Muhammed Amir
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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