Publication: Frameless hypofractionated gamma knife radiosurgery for residual or recurrent craniopharyngioma
dc.contributor.coauthor | Essibayi, Muhammed Amir | |
dc.contributor.coauthor | Askeroglu, Mehmet Orbay | |
dc.contributor.coauthor | Budak, Mustafa | |
dc.contributor.coauthor | Karakose, Fatih | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Askeroğlu, Mehmet Orbay | |
dc.contributor.kuauthor | Peker, Selçuk | |
dc.contributor.kuauthor | Budak, Mustafa | |
dc.contributor.kuauthor | Samancı, Mustafa Yavuz | |
dc.contributor.kuauthor | Karaköse, Fatih | |
dc.contributor.kuauthor | Essibayi, Muhammed Amir | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-01-19T10:34:07Z | |
dc.date.issued | 2023 | |
dc.description.abstract | BACKGROUND:The management of craniopharyngiomas is challenging, usually requiring multidisciplinary care. Gamma Knife radiosurgery (GKRS) is an essential technique for residual/recurrent craniopharyngiomas.OBJECTIVE:To evaluate the efficacy of frameless hypofractionated GKRS (hfGKRS) for craniopharyngioma and factors which affect tumor control and complications.METHODS:This retrospective study involved 24 patients managed with hfGKRS. Clinical and radiological data, tumor characteristics, and procedural details were analyzed.RESULTS:There were 15 (62.5%) female patients. The median age was 38.5 years (range, 3-66 years). The mean tumor volume was 2.4 (1.93) cm(3), with a mean solid volume of 1.6 (1.75) cm(3). The median marginal dose was 20 Gy (range, 18-25 Gy) delivered in a median of 5 fractions (range, 3-5). During a median radiological follow-up of 23.5 months (range, 12-50 months), tumor progression was noted in 5 (20.8%) patients. The 2-year and 4-year progression-free survival were 81.8% and 61.4%, respectively. No deaths were identified at a median clinical follow-up of 31.3 months (range, 12-54 months). Visual deficits attributable to progression were noted in 3 (12.5%) patients with pre-GKRS visual field defects. An additional 4 (16.7%) patients with pre-GKRS visual deficit developed new minor visual field defects. Four (16.7%) patients showed improvement of vision after GKRS. There were no new-onset post-GKRS hormonal deficits.CONCLUSION:The management of craniopharyngioma requires a multidisciplinary approach, and irradiation represents effective treatment option for residual/recurrent tumors after surgery. To the best of our knowledge, this is the first study that addresses the efficacy of frameless hfGKRS in managing craniopharyngiomas over sufficient follow-up. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 1 | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 93 | |
dc.identifier.doi | 10.1227/neu.0000000000002382 | |
dc.identifier.eissn | 1524-4040 | |
dc.identifier.issn | 0148-396X | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85163452211 | |
dc.identifier.uri | https://doi.org/10.1227/neu.0000000000002382 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/26732 | |
dc.identifier.wos | 1010656700022 | |
dc.keywords | Craniopharyngioma | |
dc.keywords | Frameless | |
dc.keywords | Hypofractionated | |
dc.keywords | Gamma Knife | |
dc.keywords | Management | |
dc.keywords | Radiosurgery | |
dc.language.iso | eng | |
dc.publisher | Lippincott Williams and Wilkins | |
dc.relation.ispartof | Neurosurgery | |
dc.subject | Medicine | |
dc.title | Frameless hypofractionated gamma knife radiosurgery for residual or recurrent craniopharyngioma | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Peker, Selçuk | |
local.contributor.kuauthor | Samancı, Mustafa Yavuz | |
local.contributor.kuauthor | Askeroğlu, Mehmet Orbay | |
local.contributor.kuauthor | Budak, Mustafa | |
local.contributor.kuauthor | Karaköse, Fatih | |
local.contributor.kuauthor | Essibayi, Muhammed Amir | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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