Publication:
Correction to: circular makerspaces as alternative employment platforms for circular jobs (Circular Economy and Sustainability, (2024), 10.1007/s43615-024-00413-2)

dc.contributor.coauthorHofgärtner R., Metta J., Schmidt A., Tsolakis A.C.
dc.contributor.departmentDepartment of Media and Visual Arts
dc.contributor.departmentKUAR (KU Arçelik Research Center for Creative Industries)
dc.contributor.kuauthorCoşkun, Aykut
dc.contributor.schoolcollegeinstituteCollege of Social Sciences and Humanities
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-03-06T20:57:46Z
dc.date.issued2024
dc.description.abstracthttps://doi.org/10.1007/s43615-024-00413-2. The original online article has been updated to remove an unrelated abstract that was accidentally added below the proper abstract of the manuscript. The wrong abstract was: "This project focused on the gene PFKFB3, a pivotal regulator of the Warburg effect, which facilitates enhanced glycolysis in cancer cells, including MCF7 human breast cancer lines. The objective was to investigate the effects of PFKFB3 knockout on the metabolic profile and proliferative capacity of MCF7 cells, hypothesizing that disruption of this gene would significantly impair cellular energy production and, consequently, cell growth. Through the application of CRISPR/Cas9 technology, PFKFB3 was specifically targeted and knocked out, followed by a meticulous process of selection to enrich for cells bearing the knockout. Growth assays, particularly MTT, were conducted to evaluate the impact of PFKFB3 deletion on cell proliferation. Contrary to expectations preliminary results indicated no significant difference in the growth rates between PFKFB3-knockout and control groups. This outcome suggests possible metabolic flexibility within MCF7 cells, allowing them to bypass the blockade of one glycolytic pathway—a concept supported by current understandings of cancer metabolism. Despite the lack of expected growth inhibition, this study provides critical insights into the adaptability of cancer cells to metabolic interventions and highlights the importance of targeting multiple metabolic pathways. Future directions will consider exploring the combined knockout of PFKFB3 and other glycolytic genes to overcome the metabolic resilience of cancer cells, thereby offering a more effective strategy for crippling cancer cell energy supplies." © The Author(s) 2024.
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1007/s43615-024-00455-6
dc.identifier.issn2730-597X
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85207015097
dc.identifier.urihttps://doi.org/10.1007/s43615-024-00455-6
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27309
dc.keywordsCapacity building
dc.keywordsCircular economy
dc.keywordsEntrepreneurship/entrepreneurial innovation
dc.keywordsMarginalised skills
dc.keywordsSocial integration
dc.keywordsSustainability
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofCircular Economy and Sustainability
dc.subjectSustainable development
dc.subjectEnvironmental impact assessment
dc.titleCorrection to: circular makerspaces as alternative employment platforms for circular jobs (Circular Economy and Sustainability, (2024), 10.1007/s43615-024-00413-2)
dc.typeOther
dc.type.otherErratum
dspace.entity.typePublication
local.publication.orgunit1College of Social Sciences and Humanities
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Media and Visual Arts
local.publication.orgunit2KUAR (KU Arçelik Research Center for Creative Industries)
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