Publication:
Robotic radical prostatectomy for prostate cancer in renal transplant recipients: results from a multicenter series

dc.contributor.coauthorMarra, Giancarlo
dc.contributor.coauthorAgnello, Marco
dc.contributor.coauthorGiordano, Andrea
dc.contributor.coauthorSoria, Francesco
dc.contributor.coauthorOderda, Marco
dc.contributor.coauthorDariane, Charles
dc.contributor.coauthorTimsit, Marc-Olivier
dc.contributor.coauthorBranchereau, Julien
dc.contributor.coauthorHedli, Oussama
dc.contributor.coauthorMesnard, Benoit
dc.contributor.coauthorOlsburgh, Jonathon
dc.contributor.coauthorKulkarni, Meghana
dc.contributor.coauthorKasivisvanathan, Veeru
dc.contributor.coauthorBreda, Alberto
dc.contributor.coauthorBiancone, Luigi
dc.contributor.coauthorGontero, Paolo
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-12-29T09:40:50Z
dc.date.issued2022
dc.description.abstractBackground: Despite an expected increase in prostate cancer (PCa) incidence in the renal transplant recipient (RTR) population in the near future, robot-assisted radical prostatectomy (RARP) in these patients has been poorly detailed. It is not well understood whether results are comparable to RARP in the non-RTR setting. Objective: To describe the surgical technique for RARP in RTR and report results from our multi-institutional experience. Design, setting, and participants: This was a retrospective review of the experience of four referral centers. Surgical procedure: Transperitoneal RARP with pelvic lymph node dissection in selected patients. Measurements: We measured patient, PCa, and graft baseline features; intraoperative and postoperative parameters; complications, (Clavien classification); and oncological and functional outcomes. Results and limitations: We included 41 men. The median age, American Society of Anesthesiologists score, preoperative renal function, and prostate-specific antigen were 60 yr (interquartile range [IQR] 57-64), 2 points (IQR 2-3), 45 ml/min (IQR 30-62), and 6.5 ng/ml (IQR 5.2-10.2), respectively. Four men (9.8%) had a biopsy Gleason score >7. The majority of the patients (70.7%) did not undergo lymphadenectomy. The median operating time, hospital stay, and catheterization time were 201 min (IQR 170-250), 4 d (IQR 2-6), and 10 d (IQR 7-13), respectively. At final pathology, 11 men had extraprostatic extension and seven had positive surgical margins. At median follow-up of 42 mo (IQR 24-65), four men had biochemical recurrence, including one case of local PCa persistence and one local recurrence. No metastases were recorded while two patients died from non-PCa-related causes. Continence was preserved in 86.1% (p not applicable) and erections in 64.7% (p = 0.0633) of those who were continent/potent before the procedure. Renal function remained unchanged (p = 0.08). No intraoperative complications and one major (Clavien 3a) complication were recorded. Conclusions: RARP in RTR is safe and feasible. Overall, operative, oncological, and functional outcomes are comparable to those described for the non-RTR setting, with graft injury remaining undescribed. Further research is needed to confirm our findings. Patient summary: Robot-assisted removal of the prostate is safe and feasible in patients who have a kidney transplant. Cancer control, urinary and sexual function results, and surgical complications seem to be similar to those for patients without a transplant, but further research is needed.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessGreen Submitted
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorsGiancarlo Marra's work at Institut Mutualiste Montsouris is funded by a grant from the European Urological Scholarship Programme.
dc.description.volume82
dc.identifier.doi10.1016/j.eururo.2022.05.024
dc.identifier.eissn1873-7560
dc.identifier.issn0302-2838
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85132824275
dc.identifier.urihttps://doi.org/10.1016/j.eururo.2022.05.024
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23459
dc.identifier.wos1044779200014
dc.keywordsProstate cancer
dc.keywordsRenal transplant
dc.keywordsTreatment
dc.keywordsRobotic radical prostatectomy
dc.languageen
dc.publisherElsevier
dc.relation.grantnoEuropean Urological Scholarship Programme
dc.sourceEuropean Urology
dc.subjectUrology
dc.subjectNephrology
dc.titleRobotic radical prostatectomy for prostate cancer in renal transplant recipients: results from a multicenter series
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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