Publication: Proteomics in cell division
dc.contributor.coauthor | N/A | |
dc.contributor.department | Department of Molecular Biology and Genetics | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.kuauthor | Kagiali, Zeynep Cansu Üretmen | |
dc.contributor.kuauthor | Küçük, Nazlı Ezgi Özkan | |
dc.contributor.kuauthor | Qureshi, Mohammad Haroon | |
dc.contributor.kuauthor | Şentürk, Aydanur | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.date.accessioned | 2024-11-09T23:59:45Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Cell division requires a coordinated action of the cell cycle machinery, cytoskeletal elements, chromosomes, and membranes. Cell division studies have greatly benefitted from the mass spectrometry (MS)-based proteomic approaches for probing the biochemistry of highly dynamic complexes and their coordination with each other as a cell progresses into division. In this review, the authors first summarize a wide-range of proteomic studies that focus on the identification of sub-cellular components/protein complexes of the cell division machinery including kinetochores, mitotic spindle, midzone, and centrosomes. The authors also highlight MS-based large-scale analyses of the cellular components that are largely understudied during cell division such as the cell surface and lipids. Then, the authors focus on posttranslational modification analyses, especially phosphorylation and the resulting crosstalk with other modifications as a cell undergoes cell division. Combining proteomic approaches that probe the biochemistry of cell division components with functional genomic assays will lead to breakthroughs toward a systems-level understanding of cell division. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 20 | |
dc.description.openaccess | NO | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 17 | |
dc.identifier.doi | 10.1002/pmic.201600100 | |
dc.identifier.eissn | 1615-9861 | |
dc.identifier.issn | 1615-9853 | |
dc.identifier.scopus | 2-s2.0-85031767837 | |
dc.identifier.uri | https://doi.org/10.1002/pmic.201600100 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/15674 | |
dc.identifier.wos | 413374500002 | |
dc.keywords | Cell division | |
dc.keywords | Cytokinesis | |
dc.keywords | Mass spectrometry | |
dc.keywords | Phosphorylation | |
dc.keywords | Proteomics | |
dc.keywords | Kinetochore-microtubule interface | |
dc.keywords | Functional genomic analysis | |
dc.keywords | Human mitotic spindle | |
dc.keywords | Mass-spectrometry | |
dc.keywords | Outer kinetochore | |
dc.keywords | Cross-linking | |
dc.keywords | Cenp-A | |
dc.keywords | Cycle progression | |
dc.keywords | Quantitative Phosphoproteomics | |
dc.keywords | Multiprotein complexes | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Proteomics | |
dc.subject | Biochemical research methods | |
dc.subject | Biochemistry | |
dc.subject | Molecular biology | |
dc.title | Proteomics in cell division | |
dc.type | Review | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Kagiali, Zeynep Cansu Üretmen | |
local.contributor.kuauthor | Şentürk, Aydanur | |
local.contributor.kuauthor | Küçük, Nazlı Ezgi Özkan | |
local.contributor.kuauthor | Qureshi, Mohammad Haroon | |
local.contributor.kuauthor | Özlü, Nurhan | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | College of Sciences | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | Department of Molecular Biology and Genetics | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
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