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Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

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Kepil, Dilay
Elmazoglu, Zubeyir
Ozogul, Naz
Gunbas, Gorkem

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Activity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (O-1(2)) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable photo-theranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.

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Elsevier

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Chemistry, applied, Engineering, chemical, Materials science, textiles

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Dyes and Pigments

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10.1016/j.dyepig.2022.111011

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