Publication: Bronchiectasis in Türkiye: data from a multicenter registry (Turkish adult bronchiectasis adtabase)
dc.contributor.coauthor | Edis, Ebru Cakir | |
dc.contributor.coauthor | Cilli, Aykut | |
dc.contributor.coauthor | Kizilirmak, Deniz | |
dc.contributor.coauthor | Coskun, Ayson Sakar | |
dc.contributor.coauthor | Guler, Nurcan | |
dc.contributor.coauthor | Cicek, Sedat | |
dc.contributor.coauthor | Sevinc, Can | |
dc.contributor.coauthor | Agca, Meltem Coban | |
dc.contributor.coauthor | Gulmez, Inci | |
dc.contributor.coauthor | Kabak, Mehmet | |
dc.contributor.coauthor | Niksarlioglu, Elif Yelda Ozgun | |
dc.contributor.coauthor | Kokturk, Nurdan | |
dc.contributor.coauthor | Sayiner, Abdullah | |
dc.contributor.kuauthor | Çağlayan, Benan Niku | |
dc.contributor.schoolcollegeinstitute | School of Medicine | |
dc.date.accessioned | 2024-12-29T09:36:29Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.indexedby | TR Dizin | |
dc.description.issue | 3 | |
dc.description.openaccess | Green Published, gold | |
dc.description.publisherscope | International | |
dc.description.volume | 41 | |
dc.identifier.doi | 10.4274/balkanmedj.galenos.2024.2023-12-57 | |
dc.identifier.eissn | 2146-3131 | |
dc.identifier.issn | 2146-3123 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85192039378 | |
dc.identifier.uri | https://doi.org/10.4274/balkanmedj.galenos.2024.2023-12-57 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/22079 | |
dc.identifier.wos | 1215913000006 | |
dc.keywords | Medicine | |
dc.language | en | |
dc.publisher | Galenos Publ House | |
dc.source | Balkan Medical Journal | |
dc.subject | Medicine | |
dc.subject | General and internal | |
dc.title | Bronchiectasis in Türkiye: data from a multicenter registry (Turkish adult bronchiectasis adtabase) | |
dc.type | Journal article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Çağlayan, Benan Niku |