Publication:
Deciphering nutritional interventions for podocyte structure and function

dc.contributor.coauthorAfşar, Barış
dc.contributor.coauthorAfşar, Rengin Elsürer
dc.contributor.coauthorCovic, Adrian
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorDemiray, Atalay
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:02:43Z
dc.date.issued2021
dc.description.abstractDespite increasing awareness and therapeutic options chronic kidney disease (CKD) is still and important health problem and glomerular diseases constitute and important percentage of CKD. Proteinuria/albuminuria is not just a marker; but it also plays a direct pathogenic role in renal disease progression of CKD. Glomerular filtration barrier (GFB) which consists of fenestrated endothelial cells, fused basal membrane and interdigitating podocyte foot process and filtration slits between foot process is the major barrier for proteinuria/albuminuria. Many glomerular diseases are characterized by disruption of GFB podocytes, foot process and slit diaphragm. Many proteinuric diseases are non-specifically targeted by therapeutic agents such as steroids and calcineurin inhibitors with systemic side effects. Thus, there is unmet need for more efficient and less toxic therapeutic options to treat glomerular diseases. In recent years, modification of dietary intake, has been gained to treat pathologic processes introducing the concept of 'food as a medicine'. The effect of various nutritional products on podocyte function and structure is also trending, especially in recent years. In the current review, we summarized the effect of nutritional interventions on podocyte function and structure.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume172
dc.identifier.doi10.1016/j.phrs.2021.105852
dc.identifier.eissn1096-1186
dc.identifier.issn1043-6618
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85113850058
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2021.105852
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16179
dc.identifier.wos696677900044
dc.keywordsFood
dc.keywordsFoot process
dc.keywordsNutrition
dc.keywordsPodocyte proteinuria
dc.keywordsSlit diaphragm
dc.language.isoeng
dc.publisherAcademic Press Ltd-Elsevier Science Ltd
dc.relation.ispartofPharmacological Research
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleDeciphering nutritional interventions for podocyte structure and function
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorDemiray, Atalay
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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