Publication: Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels
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Ormeci, Asli
Aydin, Yucel
Sumnu, Abdullah
Soyer, Ozlem Mutluay
Pinarbasi, Binnur
Gokturk, Suut
Gulluoglu, Mine
Onel, Derya
Badur, Selim
Akyuz, Filiz
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Abstract
Objectives: Serum alanine aminotransferase (ALT) is a controversial marker for disease monitoring in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The aim of this study was to determine the fibrosis stage and histological activity index (HAI) in HBeAg-negative CHB patients with persistently normal ALT (PNALT) and high serum HBV DNA (>= 2000 IU/ml) and to investigate clinical risk factors for the requirement of treatment through the examination of liver biopsy specimens.
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Elsevier Sci Ltd
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International Journal of Infectious Diseases
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DOI
10.1016/j.ijid.2016.09.007
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