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DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

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dc.contributor.coauthorMansouri, Sheila
dc.contributor.coauthorSingh, Sanjay
dc.contributor.coauthorAlamsahebpour, Amir
dc.contributor.coauthorBurrell, Kelly
dc.contributor.coauthorLi, Mira
dc.contributor.coauthorEkinci, Can
dc.contributor.coauthorKoch, Elizabeth
dc.contributor.coauthorChang, Jeffery T.
dc.contributor.coauthorWouters, Bradly
dc.contributor.coauthorAldape, Kenneth
dc.contributor.coauthorZadeh, Gelareh
dc.contributor.departmentN/A
dc.contributor.kuauthorKarabörk, Merve
dc.contributor.kuauthorSolaroğlu, İhsan
dc.contributor.kuprofileUndergraduate Student
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokidN/A
dc.contributor.yokid102059
dc.date.accessioned2024-11-09T12:26:18Z
dc.date.issued2016
dc.description.abstractThe RNAse III endonuclease DICER is a key regulator of microRNA (miRNA) biogenesis and is frequently decreased in a variety of malignancies. We characterized the role of DICER in glioblastoma (GB), specifically demonstrating its effects on the ability of glioma stem-like cells (GSCs) to form tumors in a mouse model of GB. DICER silencing in GSCs reduced their stem cell characteristics, while tumors arising from these cells were more aggressive, larger in volume, and displayed a higher proliferation index and lineage differentiation. The resulting tumors, however, were more sensitive to radiation treatment. Our results demonstrate that DICER silencing enhances the tumorigenic potential of GSCs, providing a platform for analysis of specific relevant miRNAs and development of potentially novel therapies against GB.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.versionPublisher version
dc.description.volume7
dc.formatpdf
dc.identifier.doi10.18632/oncotarget.10570
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00555
dc.identifier.issn1949-2553
dc.identifier.linkhttps://doi.org/10.18632/oncotarget.10570
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-84984903197
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1670
dc.identifier.wos386911600039
dc.keywordsGsc
dc.keywordsGlioblastoma (Gb)
dc.keywordsDicer
dc.keywordsMirna
dc.keywordsRadiation resistance
dc.languageEnglish
dc.publisherImpact Journals
dc.relation.grantnoMOP 123509
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/617
dc.sourceOncotarget
dc.subjectOncology
dc.subjectCell biology
dc.titleDICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.authorid0000-0002-9472-1735
local.contributor.kuauthorKarabörk, Merve
local.contributor.kuauthorSolaroğlu, İhsan

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