Metal-organic frameworks in biosensors

Abstract

Biosensors have emerged as powerful analytical tools with applications wide range from healthcare diagnosis to environment detection. Metal-organic frameworks (MOFs) with biosensing platforms has garnered significant attention for their superior specialties, such as increased surface area, adaptable porosity, and excellent chemical and thermal stability. This book chapter provides an overview of the recent advances in the synthesis, characterization, and applications of MOFs for biosensors. The chapter also discusses the challenges associated with MOF integration, such as biocompatibility and compatibility with biological matrices, and presents strategies to overcome these hurdles. It delves into the importance of structural and morphological analysis, surface functionalization, and stability assessment to optimize the performance and longevity of MOF-based biosensors. Moreover, it discusses advanced techniques, spectroscopy, microscopy, and electrochemical monitoring, used for interaction of biomolecules and analyte detection. It highlights the utilization of MOF-based biosensors for the analysis and quantification of biomarkers, toxins, heavy metals, pathogens, and other analytes of interest. Overall, this book chapter serves as a comprehensive resource for researchers, engineers, and practitioners study/work on biosensors who seek to explore the potential of MOFs for advancing the sensitivity, selectivity, and versatility of biosensing platforms. It provides valuable insights into the design principles, fabrication techniques, characterization methods, and applications of MOF-based biosensors, paving the way for the development of next-generation analytical tools with enhanced performance and broad societal impact. © 2024 American Chemical Society.