Publication:
Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors

dc.contributor.coauthorPaolino, G.
dc.contributor.coauthorEsposito, I.
dc.contributor.coauthorHong, S.-M.
dc.contributor.coauthorBaştürk, O.
dc.contributor.coauthorMattiolo, P.
dc.contributor.coauthorKaneko, T.
dc.contributor.coauthorVeronese, N.
dc.contributor.coauthorScarpa, A.
dc.contributor.coauthorLuchini, C.
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.yokid286248
dc.date.accessioned2024-11-09T11:42:59Z
dc.date.issued2022
dc.description.abstractAims: intraductal tubulopapillary neoplasm (ITPN)of the pancreas is a recently recognized pancreatictumor entity. Here we aimed to determine the mostimportant features with a systematic review coupledwith an integrated statistical approach.Methods and results: PubMed, SCOPUS, and Embasewere searched for studies reporting data on pancreaticITPN. The clinicopathological, immunohistochemical,and molecular data were summarized. Then a compre-hensive survival analysis and a comparative analysis ofthe molecular alterations of ITPN with those of pancre-atic ductal adenocarcinoma (PDAC) and intraductalpapillary mucinous neoplasm (IPMN) from referencecohorts (including the International Cancer GenomeConsortium- ICGC dataset and The Cancer GenomeAtlas, TCGA program) were conducted. The core find-ings of 128 patients were as follows: (i) Clinicopathologi-cal parameters: pancreatic head is the most commonsite; presence of an associated adenocarcinoma wasreported in 60% of cases, but with rare nodal metastasis.(ii) Immunohistochemistry: MUC1 (>90%) and MUC6(70%) were the most frequently expressed mucins. ITPNlacked the intestinal marker MUC2; unlike IPMN, it didnot express MUC5AC. (iii) Molecular landscape: Com-pared with PDAC/IPMN, the classic pancreatic driversKRAS,TP53,CDKN2A,SMAD4,GNAS,andRNF43were less altered in ITPN (P<0.001), whereasMCLamplifications,FGFR2fusions, andPI3KCAmutationswere commonly altered (P<0.001). (iv) Survival anal-ysis: ITPN with a “pure” branch duct involvementshowed the lowest risk of recurrence.Conclusion: ITPN is a distinct pancreatic neoplasmwith specific clinicopathological and molecular char-acteristics. Its recognition is fundamental for its clini-cal/prognostic implications and for the enrichment ofpotential targets for precision oncology.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipFondazione Cariverona Oncology Biobank Project
dc.description.sponsorshipFondazione Italiana Malattie Pancreas
dc.description.sponsorshipItalian Ministry of Health
dc.description.sponsorshipAssociazione Italiana Ricerca sul Cancro (AIRC)
dc.description.versionPublisher version
dc.description.volume81
dc.formatpdf
dc.identifier.doi10.1111/his.14698
dc.identifier.eissn1365-2559
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03656
dc.identifier.issn0309-0167
dc.identifier.linkhttps://doi.org/10.1111/his.14698
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85130685113
dc.identifier.urihttps://hdl.handle.net/20.500.14288/285
dc.identifier.wos801927600001
dc.keywordsIntraductal
dc.keywordsIPMN
dc.keywordsITPN
dc.keywordsPancreas
dc.keywordsPancreatic ductal adenocarcinoma
dc.keywordsPDAC
dc.keywordsTubulopapillary
dc.languageEnglish
dc.publisherWiley
dc.relation.grantno203885/2017
dc.relation.grantnoFIMP- J38D19000690001
dc.relation.grantnoRF CO-2019-12369662
dc.relation.grantnoCUP: B39C21000370001
dc.relation.grantno26343
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10521
dc.sourceHistopathology
dc.subjectCell Biology
dc.subjectPathology
dc.titleIntraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0002-1308-3701
local.contributor.kuauthorAdsay, Nazmi Volkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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