Publication:
Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

dc.contributor.coauthorAkolpoglu, Mukrime Birgul
dc.contributor.coauthorAlapan, Yunus
dc.contributor.coauthorDogan, Nihal Olcay
dc.contributor.coauthorBaltaci, Saadet Fatma
dc.contributor.coauthorYasa, Oncay
dc.contributor.coauthorTural, Gulsen Aybar
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSitti, Metin
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:08:04Z
dc.date.issued2022
dc.description.abstractBacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale materials, can deliver their payload to specific regions under magnetic control, enabling additional frontiers in minimally invasive medicine. However, current bacterial biohybrid designs lack high-throughput and facile construction with favorable cargoes, thus underperforming in terms of propulsion, payload efficiency, tissue penetration, and spatiotemporal operation. Here, we report magnetically controlled bacterial biohybrids for targeted localization and multistimuliresponsive drug release in three-dimensional (3D) biological matrices. Magnetic nanoparticles and nanoliposomes loaded with photothermal agents and chemotherapeutic molecules were integrated onto Escherichia coil with similar to 90% efficiency. Bacterial biohybrids, outperforming previously reported E. coli-based microrobots, retained their original motility and were able to navigate through biological matrices and colonize tumor spheroids under magnetic fields for on-demand release of the drug molecules by near-infrared stimulus. Our work thus provides a multifunctional microrobotic platform for guided locomotion in 3D biological networks and stimuli-responsive delivery of therapeutics for diverse medical applications.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue28
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipMax Planck Society This study was funded by the Max Planck Society.
dc.description.volume8
dc.identifier.doi10.1126/sciadv.abo6163
dc.identifier.issn2375-2548
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85134209364
dc.identifier.urihttps://doi.org/10.1126/sciadv.abo6163
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16873
dc.identifier.wos826385700033
dc.keywordsSalmonella-typhimurium
dc.keywordsCancer
dc.keywordsMotility
dc.keywordsPhantoms
dc.keywordsGrowth
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.ispartofScience Advances
dc.subjectMultidisciplinary sciences
dc.titleMagnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSitti, Metin
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2School of Medicine
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