Publication: Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury
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KU-Authors
KU Authors
Co-Authors
Yaman, Mesut Emre
Aydın, Hasan Emre
Güney, Güven
Bozkurt, Ismail
Paksoy, Kemal
Abdioğlu, Ahmet Atilla
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Abstract
Aim: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI). Material and Methods: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta were measured. Results: The resveratrol group had statistically significant lower levels of TNF-alpha, IL -1 beta, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells. Conclusion: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects.
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Buluş Design
Subject
Clinical neuropsychology, Surgery
Citation
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Source
Turkish Neurosurgery
Book Series Title
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DOI
10.5137/1019-5149.JTN.21829-17.3
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