Publication:
High responders are not exempt from detrimental effects of prematurely rising progesterone levels in fresh embryo transfer cycles

dc.contributor.coauthorIsiklar, Aycan
dc.contributor.coauthorBalaban, Basak
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÖktem, Özgür
dc.contributor.kuauthorUrman, Cumhur Bülent
dc.contributor.kuauthorYakın, Kayhan
dc.contributor.kuauthorYıldız, Şule
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:09:25Z
dc.date.issued2019
dc.description.abstractResearch question: Are high-responder IVF patients protected from the deleterious effect of prematurely elevated serum progesterone level on the probability of pregnancy? Design: In this retrospective cohort study, 2971 autologous fresh embryo transfer IVF cycles with gonadotrophin- releasing hormone agonist long protocol were analysed to investigate whether the detrimental effect of prematurely rising progesterone levels on clinical pregnancy rate (CPR) varies depending on the magnitude of ovarian response. Nine different evenly spaced intervals were constructed for serum progesterone level on the human chorionic gonadotrophin day (< 0.5/0.5-0.9/1-1.4/1.5-1.9/2-2.4/2.5-2.9/3-3.4/3.5-3.9/> 4 ng/ml). Then, IVF cycles in each of these intervals were further divided into low (<= 3 oocytes), normal (4-15 oocytes) and high responders (>= 16 oocytes). Results: The progressive rise of serum progesterone from the < 0.5 to the > 4 ng/ml interval caused a gradual and continuous decline in the CPR of all three types of ovarian response. The absolute difference in the CPR between the lowest and the highest progesterone groups was not related to the magnitude of ovarian response (-26.6%, -377% and -40.7% for the low, normal and high responders, respectively). On multivariate logistic regression analysis, the detrimental effect of progesterone started at 1.5-1.9 ng/ml, 3.0-3.4 ng/ml and 4.0-4.4 ng/ml intervals for the low, normal and high responders, respectively. Conclusion: High responders are not exempt from the detrimental effects of prematurely rising serum progesterone levels but the threshold interval where the detrimental effect begins is higher in the high responders compared with the low and normal responders.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume38
dc.identifier.doi10.1016/j.rbmo.2018.11.008
dc.identifier.eissn1472-6491
dc.identifier.issn1472-6483
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85058639001
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2018.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9294
dc.identifier.wos458175900010
dc.keywordsClinical pregnancy rate
dc.keywordsFSH
dc.keywordsGnRH agonist protocol
dc.keywordsHCG day
dc.keywordsPremature progesterone rise
dc.keywordsLive birth-rates
dc.keywordsIn-vitro fertilization
dc.keywordsElevated serum progesterone
dc.keywordsOvarian stimulation
dc.keywordsFollicular phase
dc.keywordsWomen
dc.keywordsPregnancy
dc.keywordsIVF
dc.keywordsNumber
dc.keywordsImpact
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofReproductive Biomedicine Online
dc.subjectObstetrics
dc.subjectGynecology
dc.subjectReproductive biology
dc.titleHigh responders are not exempt from detrimental effects of prematurely rising progesterone levels in fresh embryo transfer cycles
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÖktem, Özgür
local.contributor.kuauthorYakın, Kayhan
local.contributor.kuauthorOğuz, Şule Yıldız
local.contributor.kuauthorUrman, Cumhur Bülent
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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