Investigation of the predictive value of de Ritis ratio and inflammatory markers in prostate cancer patients suitable for active surveillance

Abstract

Objective: To demonstrate the role of inflammatory markers and the De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) in selecting patients with localized prostate cancer for active surveillance. Methods: A total of 83 patients who met the criteria for active surveillance and underwent radical prostatectomy in our clinic between January 2010 and June 2017 were included in the study. Preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-tohemoglobin (Plt/Hb) ratio, red cell distribution width (RDW), and De Ritis ratio were retrospectively evaluated with postoperative outcomes. Results: NLR, PLR, RDW, and Plt/Hb ratios were not significantly associated with upgrade and upstage. Twenty-three patients (27.7%) underwent upgrade, 10 patients (12%) underwent upstage, and 29 patients (34.9%) were found unsuitable for active surveillance of radical prostatectomy results. A high De Ritis ratio was significantly associated with increased upgrade and unsuitability for active surveillance. Conclusion: Preoperatively, a high De Ritis ratio is associated with poor pathological outcomes, and a high De Ritis ratio can be used as a costeffective and accessible marker for selecting patients for active surveillance.