Mapping the scientific output of stem cell therapy in neonates: a bibliometric study

Abstract

To conduct a bibliometric analysis on stem cell therapy in neonates, identifying key trends, prolific authors, influential institutions, and research collaborations to provide a structured overview of the field's development. Methods: A bibliometric approach was employed, analyzing the literature indexed in major academic databases (Web of Science, Scopus, and PubMed). Publications between 2000 and 2024 were retrieved using specific keywords related to neonatal stem cell therapy. Data analysis was performed using VOSviewer and Microsoft Excel to evaluate publication trends, citation metrics, authorship networks, keyword co-occurrences, and geographical distribution. Results: A total of 585 relevant articles were identified, with a significant increase in publication output observed over the last decade. The most researched neonatal condition was HIE, followed by BPD and NEC. Mesenchymal stem cells (MSCs) emerged as the most studied stem cell type. The United States, China, and Europe accounted for most publications, while low-and middle-income countries had minimal contributions, highlighting global research disparities. Citation analysis revealed the most influential studies as preclinical and early-phase clinical trials. Emerging trends include the integration of bioengineered scaffolds, organoid models, artificial intelligence, and gene-editing techniques in neonatal stem cell research. Conclusions: The bibliometric analysis demonstrates a growing research interest in neonatal stem cell therapy, with a focus on HIE, BPD, and NEC. Despite significant advancements, challenges remain in terms of clinical translation, ethical considerations, and global accessibility. Future research should emphasize large-scale clinical trials, cross-disciplinary collaborations, and equitable distribution of research efforts to ensure that stem cell therapies benefit neonates worldwide.