Publication:
Technical aspects and difficulties in the management of head and neck cutaneous malignancies in xeroderma pigmentosum

dc.contributor.coauthorSibar, Serhat
dc.contributor.coauthorFındıkçıoğlu, Kemal
dc.contributor.coauthorErdal, Ayhan Işık
dc.contributor.coauthorBarut, İsmail
dc.contributor.departmentN/A
dc.contributor.kuauthorÖzmen, Selahattin
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.unitKoç University Hospital
dc.contributor.yokid125951
dc.date.accessioned2024-11-10T00:11:42Z
dc.date.issued2016
dc.description.abstractBackground Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment. Methods Between 2005 and 2015, 11 XP patients with head and neck cutaneous malignancies were included in this study. Demographic data and treatment options of the patients were evaluated. Results The mean age of the patients was 32 years (range, 10-43) (4 males, 7 females). The most common tumor type and location were squamous cell carcinoma (6 patients) and the orbital region (4 patients), respectively. Free tissue transfer was the most commonly performed surgical intervention (4 patients). The average number of surgical procedures was 5.5 (range, 1-25). Six patients were siblings with each other, 5 patients had local recurrences, and one patient was lost to follow-up. Conclusions Although genetic components of the disease have been elucidated, there is no definitive treatment algorithm. Early surgical intervention and close follow-up are the gold standard modalities due to the tendency toward rapid tumor growth and possible recurrence. Treatment must be individualized for each patient. In addition, the psychological aspect of the disease is an important issue for both patients and families.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.volume43
dc.identifier.doi10.5999/aps.2016.43.4.344
dc.identifier.eissn2234-6171
dc.identifier.issn2234-6163
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-84982293434
dc.identifier.urihttp://dx.doi.org/10.5999/aps.2016.43.4.344
dc.identifier.urihttps://hdl.handle.net/20.500.14288/17530
dc.identifier.wos387070400007
dc.keywordsSkin neoplasms
dc.keywordsHead and neck neoplasms
dc.keywordsXeroderma pigmentosum
dc.keywordsFree tissue flaps
dc.languageEnglish
dc.publisherKorean Soc Plastic & Reconstructive Surgery
dc.sourceArchives of Plastic Surgery-Aps
dc.subjectSurgery
dc.titleTechnical aspects and difficulties in the management of head and neck cutaneous malignancies in xeroderma pigmentosum
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-0259-2578
local.contributor.kuauthorÖzmen, Selahattin

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