Publication: From corrosion behavior to radiation response: a comprehensive biocompatibility assessment of a cocrmo medium entropy alloy for utility in orthopedic and dental implants
dc.contributor.coauthor | Gerstein, G. | |
dc.contributor.coauthor | Maier, H. J. | |
dc.contributor.coauthor | Cabuk, H. | |
dc.contributor.coauthor | Bukulmez, T. | |
dc.contributor.coauthor | Cananoglu, M. | |
dc.contributor.coauthor | Toker, S. M. | |
dc.contributor.coauthor | Gunes, S. | |
dc.contributor.coauthor | Soykan, M. N. | |
dc.contributor.department | Department of Mechanical Engineering | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.department | KUYTAM (Koç University Surface Science and Technology Center) | |
dc.contributor.kuauthor | Canadinç, Demircan | |
dc.contributor.kuauthor | Gürel, Şeyma | |
dc.contributor.kuauthor | Nazarahari, Alireza | |
dc.contributor.kuauthor | Yağcı, Mustafa Barış | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.date.accessioned | 2024-11-09T23:36:55Z | |
dc.date.issued | 2022 | |
dc.description.abstract | This paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic exper-iments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hy-droxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | BAGEP Award of the Science Academy | |
dc.description.sponsorship | Kog University Graduate School of Sciences and Engineering | |
dc.description.sponsorship | Deutsche For-schungsgemeinschaft [426335750] | |
dc.description.sponsorship | Eskisehir Osmangazi University BAP research funds [2018/15038] This study was supported by the BAGEP Award of the Science Academy. The authors also acknowledge the financial support by the Kog University Graduate School of Sciences and Engineering. The German part of the study was supported by Deutsche For-schungsgemeinschaft (project number 426335750) . S.M. Toker ac-knowledges the support by Eskisehir Osmangazi University BAP research funds (Grant 2018/15038) . | |
dc.description.volume | 149 | |
dc.identifier.doi | 10.1016/j.intermet.2022.107680 | |
dc.identifier.eissn | 1879-0216 | |
dc.identifier.issn | 0966-9795 | |
dc.identifier.scopus | 2-s2.0-85135692388 | |
dc.identifier.uri | https://doi.org/10.1016/j.intermet.2022.107680 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/12742 | |
dc.identifier.wos | 849678200002 | |
dc.keywords | Cocrmo | |
dc.keywords | Corrosion | |
dc.keywords | Irradiation | |
dc.keywords | Biocompatibility | |
dc.keywords | Orthopedic implant | |
dc.keywords | Dental implant fetal bovine serum | |
dc.keywords | Bonelike apatite formation | |
dc.keywords | Simulated body-fluid | |
dc.keywords | Passive oxide layer | |
dc.keywords | Co-Cr | |
dc.keywords | Surface-analysis | |
dc.keywords | Ion release | |
dc.keywords | Biomedical applications | |
dc.keywords | Mechanical-properties | |
dc.keywords | Metal | |
dc.language.iso | eng | |
dc.publisher | Elsevier Sci Ltd | |
dc.relation.ispartof | Intermetallics | |
dc.subject | Chemistry | |
dc.subject | Physical | |
dc.subject | Materials science | |
dc.subject | Engineering | |
dc.subject | Metallurgy metallurgical engineering | |
dc.title | From corrosion behavior to radiation response: a comprehensive biocompatibility assessment of a cocrmo medium entropy alloy for utility in orthopedic and dental implants | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Gürel, Şeyma | |
local.contributor.kuauthor | Nazarahari, Alireza | |
local.contributor.kuauthor | Canadinç, Demircan | |
local.contributor.kuauthor | Yağcı, Mustafa Barış | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | Department of Mechanical Engineering | |
local.publication.orgunit2 | KUYTAM (Koç University Surface Science and Technology Center) | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
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