Publication:
From corrosion behavior to radiation response: a comprehensive biocompatibility assessment of a cocrmo medium entropy alloy for utility in orthopedic and dental implants

dc.contributor.coauthorGerstein, G.
dc.contributor.coauthorMaier, H. J.
dc.contributor.coauthorCabuk, H.
dc.contributor.coauthorBukulmez, T.
dc.contributor.coauthorCananoglu, M.
dc.contributor.coauthorToker, S. M.
dc.contributor.coauthorGunes, S.
dc.contributor.coauthorSoykan, M. N.
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.kuauthorCanadinç, Demircan
dc.contributor.kuauthorGürel, Şeyma
dc.contributor.kuauthorNazarahari, Alireza
dc.contributor.kuauthorYağcı, Mustafa Barış
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T23:36:55Z
dc.date.issued2022
dc.description.abstractThis paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic exper-iments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hy-droxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipBAGEP Award of the Science Academy
dc.description.sponsorshipKog University Graduate School of Sciences and Engineering
dc.description.sponsorshipDeutsche For-schungsgemeinschaft [426335750]
dc.description.sponsorshipEskisehir Osmangazi University BAP research funds [2018/15038] This study was supported by the BAGEP Award of the Science Academy. The authors also acknowledge the financial support by the Kog University Graduate School of Sciences and Engineering. The German part of the study was supported by Deutsche For-schungsgemeinschaft (project number 426335750) . S.M. Toker ac-knowledges the support by Eskisehir Osmangazi University BAP research funds (Grant 2018/15038) .
dc.description.volume149
dc.identifier.doi10.1016/j.intermet.2022.107680
dc.identifier.eissn1879-0216
dc.identifier.issn0966-9795
dc.identifier.scopus2-s2.0-85135692388
dc.identifier.urihttps://doi.org/10.1016/j.intermet.2022.107680
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12742
dc.identifier.wos849678200002
dc.keywordsCocrmo
dc.keywordsCorrosion
dc.keywordsIrradiation
dc.keywordsBiocompatibility
dc.keywordsOrthopedic implant
dc.keywordsDental implant fetal bovine serum
dc.keywordsBonelike apatite formation
dc.keywordsSimulated body-fluid
dc.keywordsPassive oxide layer
dc.keywordsCo-Cr
dc.keywordsSurface-analysis
dc.keywordsIon release
dc.keywordsBiomedical applications
dc.keywordsMechanical-properties
dc.keywordsMetal
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofIntermetallics
dc.subjectChemistry
dc.subjectPhysical
dc.subjectMaterials science
dc.subjectEngineering
dc.subjectMetallurgy metallurgical engineering
dc.titleFrom corrosion behavior to radiation response: a comprehensive biocompatibility assessment of a cocrmo medium entropy alloy for utility in orthopedic and dental implants
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGürel, Şeyma
local.contributor.kuauthorNazarahari, Alireza
local.contributor.kuauthorCanadinç, Demircan
local.contributor.kuauthorYağcı, Mustafa Barış
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Engineering
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2KUYTAM (Koç University Surface Science and Technology Center)
local.publication.orgunit2Graduate School of Sciences and Engineering
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