Publication:
Prognostic scores in pulmonary large cell neuroendocrine carcinoma: a retrospective cohort study

Placeholder

Organizational Units

Program

KU-Authors

KU Authors

Co-Authors

Akdağ, Goncagül
Doğan, Akif
Yıldırım, Sedat
Kınıkoğlu, Oğuzcan
Batu, Aziz
Kudu, Emre
Geçmen, Gonca Gül
Işık, Deniz
Sever, Özlem Nuray
Odabaş, Hatice

Advisor

Publication Date

2024

Language

en

Type

Journal article

Journal Title

Journal ISSN

Volume Title

Abstract

Introduction: Pulmonary large cell neuroendocrine carcinoma (PLCNEC) is a rare but aggressive subtype of lung cancer with an incidence of approximately 3 %. Identifying effective prognostic indicators is crucial for guiding treatments. This study examined the relationship between inflammatory markers and PLCNEC patient overall survival (OS) and sought to determine their prognostic significance in PLCNEC. Methods: Patients diagnosed with PLCNEC between 2007 and 2022 at the oncology center, were retrospectively included. Patients who underwent surgery were pathologically re-staged postsurgery. Potential prognostic parameters (neutrophil/lymphocyte ratio, platelet/lymphocyte ratio [PLR], panimmune inflammatory value, prognostic nutritional index and modified Glasgow prognostic score [mGPS]) were calculated at that time of diagnosis. Results: Sixty patients were included. The median follow-up was 23 months. Thirty-eight patients initially diagnosed with early or locally advanced. The mGPS was identified as a poor prognostic factor that influenced disease free survival (DFS) fourfold (p = 0.03). All patients' median OS was 45 months. Evaluating factors affecting OS in all patients, statistically significant relationships were observed between OS and the prognostic nutritional index (p = 0.001), neutrophil/ lymphocyte ratio (p = 0.03), platelet/lymphocyte ratio (p = 0.002), and panimmunoinflammatory value (p = 0.005). Upon multivariate analysis, the platelet/lymphocyte ratio was identified as an independent poor prognostic factor for OS, increasing the mortality risk by 5.4 times (p = 0.002). Conclusion: mGPS was significantly linked with prognosis in non-metastatic PLCNEC, with patients with higher mGPS exhibiting poorer long -term DFS. This finding contributes to the evolving understanding of PLCNEC. The multivariable predictive model we employed suggests that PLR is an independent predictor of OS at all stages. A lower PLR was correlated with worse overall survival. Thus, PLR can be a readily accessible and cost-effective prognostic factor in PLCNEC patients.

Description

Source:

Heliyon

Publisher:

Cell Press

Keywords:

Subject

Carcinoid, Lung tumor, Computed tomography

Citation

Endorsement

Review

Supplemented By

Referenced By

Copy Rights Note

0

Views

0

Downloads

View PlumX Details