Publication:
Disease course and treatment response of eosinophilic gastrointestinal diseases in children with liver transplantation: long-term follow-up

dc.contributor.coauthorDoğanay, Latife
dc.contributor.coauthorCan, Demet
dc.contributor.departmentN/A
dc.contributor.kuauthorArıkan, Çiğdem
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileUndergraduate Student
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid240198
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T23:35:15Z
dc.date.issued2021
dc.description.abstractINTRODUCTION: To describe the clinical and laboratory profile, natural course, treatment outcome, and risk factors of posttransplant esophageal and nonesophageal eosinophilic gastrointestinal disorders (EGIDs). METHODS: All children (aged <18 years) who underwent liver transplantation, between 2011 and 2019, in a single transplant center with a follow-up period of 1 year or more posttransplant and with a history of posttransplant endoscopic evaluation were included in this study. RESULTS: During the study period, 89 children met the inclusion criteria. Patients were followed for a median of 8.0 years. A total of 39 (44%) patients were diagnosed with EGID after transplantation. of these, 29 (33%) had eosinophilic esophagitis (EoE), and 10 (11%) had eosinophilic gastritis, gastroenteritis or enterocolitis. In comparison with the non-EGID group, patients with EGID were younger at transplant (P <= 0.0001), transplanted more frequently due to biliary atresia (P <= 0.0001), and had higher rates of pretransplant allergy (P = 0.019). In the posttransplant period, they had higher rates of mammalian Target of Rapamycin inhibitor use (P = 0.006), Epstein-Barr virus viremia (P = 0.03), post-transplant lymphoproliferative disease (P = 0.005), and allergen sensitization (P <= 0.0001). In regression analysis, young age at transplant, age at diagnosis, pretransplant atopic dermatitis, and post-transplant lymphoproliferative disease were associated with an increased risk of EGID or EoE. Laboratory abnormalities such as anemia (P = 0.007), thrombocytosis (P = 0.012), and hypoalbuminemia (P = 0.031) were more commonly observed in the eosinophilic gastritis, gastroenteritis or enterocolitis group than in the EoE group. Following treatment, most patients had symptomatic resolution at 3 months and histologic resolution at 6 months postdiagnosis. Among the patients who had 5 years of follow-up, none recurred. DISCUSSION: EGID is a common posttransplant diagnosis, which seems to affect patients who are transplanted earlier and who have pretransplant atopy. Posttransplant EGID is responsive to treatment, but as histologic remission occurs after symptomatic resolution, the decision to perform control endoscopy should be delayed.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume116
dc.identifier.doi10.14309/ajg.0000000000000934
dc.identifier.eissn1572-0241
dc.identifier.issn0002-9270
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85099322587
dc.identifier.urihttp://dx.doi.org/10.14309/ajg.0000000000000934
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12472
dc.identifier.wos607726100028
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.sourceAmerican Journal of Gastroenterology
dc.subjectGastroenterology and hepatology
dc.titleDisease course and treatment response of eosinophilic gastrointestinal diseases in children with liver transplantation: long-term follow-up
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-0794-2741
local.contributor.authorid0000-0002-2303-8648
local.contributor.kuauthorArıkan, Çiğdem
local.contributor.kuauthorÖzdoğan, Elif

Files