Publication:
Distribution of dysplasia and cancer in the gallbladder: an analysis from a high cancer-risk population

dc.contributor.coauthorKoshiol, Jill
dc.contributor.coauthorBellolio, Enrique
dc.contributor.coauthorVivallo, Carolina
dc.contributor.coauthorCook, Paz
dc.contributor.coauthorCarlos Roa, Juan
dc.contributor.coauthorMcGee, Emma E.
dc.contributor.coauthorLosada, Hector
dc.contributor.coauthorVan Dyke, Alison L.
dc.contributor.coauthorVan De Wyngard, Vanessa
dc.contributor.coauthorPrado, Rodrigo
dc.contributor.coauthorVillaseca, Miguel
dc.contributor.coauthorRiquelme, Pia
dc.contributor.coauthorAcevedo, Johanna
dc.contributor.coauthorOlivo, Vanessa
dc.contributor.coauthorPettit, Karen
dc.contributor.coauthorHildesheim, Allan
dc.contributor.coauthorMedina, Katie
dc.contributor.coauthorMemis, Bahar
dc.contributor.coauthorFerreccio, Catterina
dc.contributor.coauthorCarlos Araya, Juan
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:45:47Z
dc.date.issued2018
dc.description.abstractGallbladder dysplasia can progress to cancer and may be associated with increased cancer risk at other biliary tract sites. Thus, its accurate identification is relevant both for etiologic understanding and for clinical purposes. Data on the frequency and distribution of gallbladder dysplasia are lacking owing to limited gallbladder sampling and inability to visualize dysplasia grossly. An expert pathology group used consensus criteria to review 140 totally sampled consecutive cholecystectomy specimens from Chilean women. Three cases (2%) revealed incidental invasive carcinoma, all T2, along with high-grade dysplasia (HGD). The surface areas covered by dysplasia or cancer in these cases were 9%, 37%, and 87%. Although the first longitudinal ("diagnostic") section of the whole gallbladder captured HGD or cancer in all 3 cases, the deepest focus of invasive carcinoma was not present in this section. Fourteen additional cases (10%) had low-grade dysplasia (LGD), which was typically very focal (covering <5% of the surface) and most often occurred in the fundus. LGD was not present in the diagnostic section of 5 cases (38%) and would have been missed without additional sampling. None of the cancers or dysplasias were grossly visible. Although HGD and carcinoma are likely to be identified in "diagnostic" sections, accurate staging requires total sampling. LGD is typically very focal and would often be missed in routine practice. To identify cancer precursors, additional sampling, particularly of the fundus, may be warranted. The predominance of LGD in the fundus also provides etiologic insight, supporting the contribution of gallstones and chronic inflammation.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis work was supported by general funds from the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, and the Office of Research on Women's Health, National Institutes of Health.
dc.description.volume82
dc.identifier.doi10.1016/j.humpath.2018.07.015
dc.identifier.eissn1532-8392
dc.identifier.issn0046-8177
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85055292571
dc.identifier.urihttps://doi.org/10.1016/j.humpath.2018.07.015
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13873
dc.identifier.wos454968800011
dc.keywordsDysplasia
dc.keywordsInvasive carcinoma
dc.keywordsGallbladder cancer
dc.keywordsSampling
dc.keywordsHistopathology
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofHuman Pathology
dc.subjectPathology
dc.titleDistribution of dysplasia and cancer in the gallbladder: an analysis from a high cancer-risk population
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAdsay, Nazmi Volkan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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