Publication:
An information theoretical analysis of multi-terminal neuro-spike communication network in spinal cord

dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAkan, Özgür Barış
dc.contributor.kuauthorCivaş, Meltem
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T13:19:06Z
dc.date.issued2018
dc.description.abstractCommunication theoretical understanding of healthy and diseased connections in the spinal cord motor system is crucial for realizing future information and communication technology (ICT) based diagnosis and treatment techniques for spinal cord injuries (SCI). A spinal cord motor nucleus associated with a particular muscle constitutes an ideal candidate for studying to have an understanding of SCI. Typical spinal cord motor nucleus system contains pool of lower motor neurons (MNs) controlling a muscle by integrating synaptic inputs from spinal interneurons (INs), upper motor neurons (DNs) and sensory neurons (SNs). In this study, we consider this system from ICT perspective. Our aim is to quantify the rate of information flow across a spinal cord motor nucleus. To this end, we model an equivalent single-hop multiterminal network, where multiple transmitting nodes representing heterogeneous population of DNs, INs and SNs sen information to multiple receiving nodes corresponding to MNs. To identify the outputs at receiving nodes, we define corresponding neurospike communication channel and then find the bound on total rates across this network. Based on the network model, we analyze achievable rates for a particular motor nucleus system called Tibialis Anterior (TA) motor nucleus in the spinal cord numerically and simulate several spinal cord dysfunction scenarios. The numerical results reveal that decrease in the maximum total rates with the lower motor neuron injury causes weakness in the affected muscle.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipEuropean Union (European Union)
dc.description.sponsorshipEuropean Research Council (ERC) Projects MINERVA
dc.description.sponsorshipEuropean Research Council (ERC) Proof of Concept Project MINERGRACE
dc.description.versionAuthor's final manuscript
dc.identifier.doi10.1145/3233188.3233215
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01751
dc.identifier.isbn9781450357111
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85055849688
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3081
dc.identifier.wos457917300006
dc.keywordsHardware and architecture
dc.keywordsEngineering, electrical and electronic
dc.keywordsTelecommunications
dc.keywordsSpinal cord injuries
dc.keywordsICT-based treatments
dc.keywordsNanonetworks
dc.keywordsMulti-terminal networks
dc.keywordsNeuro-spike communication
dc.language.isoeng
dc.publisherAssociation for Computing Machinery (ACM)
dc.relation.grantnoERC-2013-CoG, 616922
dc.relation.grantnoERC-2017-PoC, 780645
dc.relation.ispartofNANOCOM '18: Proceedings of the 5th ACM International Conference on Nanoscale Computing and Communication
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8532
dc.subjectComputer science
dc.subjectNanoscience and nanotechnology
dc.titleAn information theoretical analysis of multi-terminal neuro-spike communication network in spinal cord
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorAkan, Özgür Barış
local.contributor.kuauthorCivaş, Meltem
local.publication.orgunit1College of Engineering
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Department of Electrical and Electronics Engineering
local.publication.orgunit2Graduate School of Sciences and Engineering
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