Publication:
Immature platelet fraction: is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?

dc.contributor.coauthorTaşdemir, Zeynep Atam
dc.contributor.coauthorPaloğlu, Kerim Erhan
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAkpınar, Timur Selçuk
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.kuauthorÇaltı, Hatice Kant
dc.contributor.kuauthorDağel, Tuncay
dc.contributor.kuauthorİncir, Said
dc.contributor.kuauthorKapmaz, Mahir
dc.contributor.kuauthorKılıç, Alparslan
dc.contributor.kuauthorKomesli, Zeynep
dc.contributor.kuauthorOkan, Ayşe
dc.contributor.kuauthorSomay, Kayra
dc.contributor.kuauthorTekin, Süda
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:40:19Z
dc.date.issued2021
dc.description.abstractObjectives: in many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed to investigate the predictive value of IPF% for the severity of pneumonia in patients with Coronavirus Disease 2019 (COVID-19). Methods: a total of 154 patients with COVID-19 infections were included. The patients were divided into two groups according to the severity of pneumonia (severe and nonsevere) regarding their oxygen demand. Results: given laboratory parameters, the median IPF% was significantly higher in the severe group (11.9 vs. 3.9%, p<0.001). Mean platelet volume (p<0.001), platelet-large cell ratio (p=0.001), platelet distribution width (p=0.001), D-Dimer (p<0.001), INR (p=0.003), and aPTT (p=0.007) were also found to be significantly higher in the severe group. Moreover, IPF (p=0.014, Odds ratio = 2.000, 95%CI: 1.149-3.482) was an independent predictor for the severity. The curve value from receiver operating characteristics was 0.879 (p<0.001, 95%CI: 0.784-0.943) for determining the severity of pneumonia. IPF% had a sensitivity and specificity value of 69.5 and 92.4% to detect the disease's severity. Conclusions: IPF% is an independent predictor for the severity of COVID-19 pneumonia. Assessment of IPF% may both help to early determine high-risk patients with COVID-19 and to alert the physicians. / Amaç: pek çok hastalıkta, immatür platelet fraksiyonu (%İPF), koagülopati ve kötü sonuçla ilişkilidir. Bu çalışma, Coronavirus Hastalığı 2019 (COVID-19) olan hastalarda pnömoni şiddeti için %İPF’nin prediktif değerini araştırmayı amaçladı. Yöntem: COVID-19 enfeksiyonu olan toplam 154 hasta dahil edildi. Hastalar, oksijen ihtiyaçları göz önüne alınarak pnömoni şiddetine göre (ağır ve ağır olmayan) iki gruba ayrıldı. Bulgular: laboratuvar parametrelerine bakıldığında, medyan İPF yüzdesi ağır grupta anlamlı olarak daha yüksekti (% 11.9?a karşı %3.9, p<0.001). Ortalama trombosit hacmi (p<0.001), trombosit-büyük hücre oranı (p=0.001), trombosit dağılım genişliği (p=0.001), D-Dimer (p<0.001),İNR (p=0.003) ve aPTT (p=0.007) ağır grupta anlamlı olarak daha yüksek bulundu. Ayrıca, İPF (p=0.014, Odds oranı = 2.000, %95 CI: 1.149-3.482) hastalık şiddeti için bağımsız bir öngördürücü olarak bulundu. Algılayıcı işletim eğrisinden gelen eğri değeri, pnömoni şiddetini belirlemek için 0.879 (p<0.001, % 95 CI: 0.784-0.943) idi. İPF, hastalığın şiddetini saptamak için %69.5?lik duyarlılık ve %92.4?lük özgüllük değerine sahipti. Sonuç: İPF, COVID-19 pnömonisinin şiddeti için bağımsız bir öngörücüdür. %İPF’nin değerlendirilmesi, hem COVID-19? lu yüksek riskli hastaları erken belirlemeye hem de hekimleri uyarmaya yardımcı olabilir.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyTR Dizin
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume46
dc.identifier.doi10.1515/tjb-2021-0070
dc.identifier.eissn1303-829X
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03195
dc.identifier.issn0250-4685
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85115384573
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2177
dc.identifier.wos693607700004
dc.keywordsBiomarker
dc.keywordsBlood cell count
dc.keywordsCOVID-19
dc.keywordsImmature platelet fraction
dc.keywordsSARS-CoV-2
dc.language.isoeng
dc.publisherDe Gruyter
dc.relation.grantnoNA
dc.relation.ispartofTurkish Journal of Biochemistry / Türk Biyokimya Dergisi
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9957
dc.subjectBiochemistry
dc.subjectMolecular biology
dc.titleImmature platelet fraction: is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?
dc.title.alternativeImmatür platelet fraksiyonu: Covid-19 pnömonisi olan hastalarda hastalık şiddeti için yeni bir erken prediktif belirteç olabilir mi?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorİncir, Said
local.contributor.kuauthorKomesli, Zeynep
local.contributor.kuauthorBaygül, Arzu Eden
local.contributor.kuauthorÇaltı, Hatice Kant
local.contributor.kuauthorKapmaz, Mahir
local.contributor.kuauthorTekin, Süda
local.contributor.kuauthorKılıç, Alparslan
local.contributor.kuauthorDağel, Tuncay
local.contributor.kuauthorOkan, Ayşe
local.contributor.kuauthorSomay, Kayra
local.contributor.kuauthorAkpınar, Timur Selçuk
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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