Publication:
Renal hyperfiltration defined by high estimated glomerular filtration rate: a risk factor for cardiovascular disease and mortality

dc.contributor.coauthorAfsar, Baris
dc.contributor.coauthorOrtiz, Alberto
dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorKuwabara, Masanari
dc.contributor.coauthorCherney, David Z. I.
dc.contributor.coauthorvan Raalte, Daniel H.
dc.contributor.coauthorde Zeeuw, Dick
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErtuğlu, Lale Aslıhan
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorKüçüksümer, Zeynep
dc.contributor.kuauthorÖzdoğan, Elif
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:06:58Z
dc.date.issued2019
dc.description.abstractRenal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all-cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue11
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume21
dc.identifier.doi10.1111/dom.13831
dc.identifier.eissn1463-1326
dc.identifier.issn1462-8902
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85073486108
dc.identifier.urihttps://doi.org/10.1111/dom.13831
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9064
dc.identifier.wos479641000001
dc.keywordsCardiovascular disease
dc.keywordsCardiovascular mortality
dc.keywordsDiabetes
dc.keywordsGlomerular hyperfiltration
dc.keywordsRenal hyperfiltration
dc.language.isoeng
dc.publisherWiley
dc.relation.grantnoMinistry of Development Ministry of Development
dc.relation.ispartofDIABETES OBESITY & METABOLISM
dc.subjectEndocrinology
dc.subjectMetabolism
dc.titleRenal hyperfiltration defined by high estimated glomerular filtration rate: a risk factor for cardiovascular disease and mortality
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorErtuğlu, Lale Aslıhan
local.contributor.kuauthorÖzdoğan, Elif
local.contributor.kuauthorKüçüksümer, Zeynep
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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