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Why we should be more careful using hydroxychloroquine in influenza season?

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dc.contributor.coauthorÇelik, Hülya Gamze
dc.contributor.coauthorKeske, Şiran
dc.contributor.coauthorŞener, Ülker
dc.contributor.coauthorŞahin, Şükrü Taylan
dc.contributor.coauthorÖzyıldırım, Aslı
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAytekin, Saide
dc.contributor.kuauthorAytekin, Vedat
dc.contributor.kuauthorKapmaz, Mahir
dc.contributor.kuauthorTekbaş, Müge
dc.contributor.kuauthorErgönül, Önder
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:40:40Z
dc.date.issued2020
dc.description.abstractThe aim of this study was to describe the QTc prolongation and related adverse cardiac events during the administration of hydroxychloroquine (HCQ) and its combinations for the treatment of coronavirus disease 2019 (COVID-19). Hospitalized patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who received HCQ and had initial and follow-up electrocardiograms performed between March 10 and May 30, 2020 were included. Critical QTc prolongation was detected in 12% of the patients. On multivariate analysis, diabetes mellitus (odds ratio 5.8, 95% confidence interval 1.11–30.32, p = 0.037) and the use of oseltamivir (odds ratio 5.3, 95% confidence interval 1.02–28, p = 0.047) were found to be associated with critical QTc prolongation.
dc.description.fulltextYES
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume102
dc.identifier.doi10.1016/j.ijid.2020.10.080
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02505
dc.identifier.issn1201-9712
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85096821934
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2203
dc.keywordsHydroxychloroquine
dc.keywordsCOVID-19
dc.keywordsPredictors
dc.keywordsQT prolongation
dc.keywordsCardiac events
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnoNA
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9315
dc.subjectMedicine
dc.titleWhy we should be more careful using hydroxychloroquine in influenza season?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTekbaş, Müge
local.contributor.kuauthorKapmaz, Mahir
local.contributor.kuauthorAytekin, Saide
local.contributor.kuauthorAytekin, Vedat
local.contributor.kuauthorErgönül, Mehmet Önder
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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