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Modeling and analysis of the cross-talk regulators between the AKT and ERK signaling pathways

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dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorArkun, Yaman
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T12:11:58Z
dc.date.issued2019
dc.description.abstractThe cross-talk between different signal transduction pathways plays a key role in the regulation of cellular functions. This paper models the major feedback loops involved in the cross-talk between AKT and ERK signaling pathways. The developed models can be used to improve our understanding of the complex interactions between two important pathways at the systems level.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.versionPublisher version
dc.identifier.doi10.1016/j.ifacol.2019.06.115
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01771
dc.identifier.issn2405-8963
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85070541610
dc.identifier.urihttps://doi.org/10.1016/j.ifacol.2019.06.115
dc.identifier.wos473270600088
dc.keywordsCross-talk
dc.keywordsCellular signaling
dc.keywordsERK dynamics
dc.keywordsAKT pathway
dc.keywordsBistability
dc.keywordsFeedback regulation
dc.keywordsModeling
dc.keywordsBifurcation
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantno117F123
dc.relation.ispartofIFAC-PapersOnLine
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8369
dc.subjectScience and technology
dc.subjectChemical and biological engineering
dc.titleModeling and analysis of the cross-talk regulators between the AKT and ERK signaling pathways
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorArkun, Yaman
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
relation.isOrgUnitOfPublicationc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isOrgUnitOfPublication.latestForDiscoveryc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

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