Publication:
Pediatric-onset chronic inflammatory demyelinating polyneuropathy: a multicenter study

dc.contributor.coauthorUzan, Gamze Sarikaya
dc.contributor.coauthorYuksel, Deniz
dc.contributor.coauthorAksoy, Erhan
dc.contributor.coauthorOztoprak, Ulkuhan
dc.contributor.coauthorCanpolat, Mehmet
dc.contributor.coauthorOzturk, Selcan
dc.contributor.coauthorYildirim, Celebi
dc.contributor.coauthorGulec, Ayten
dc.contributor.coauthorPer, Huseyin
dc.contributor.coauthorGumus, Hakan
dc.contributor.coauthorOkuyaz, Cetin
dc.contributor.coauthorDirek, Meltem Cobanoullari
dc.contributor.coauthorKosmur, Mustafa
dc.contributor.coauthorUnalp, Aycan
dc.contributor.coauthorYilmaz, Unsal
dc.contributor.coauthorBektas, Omer
dc.contributor.coauthorTeber, Serap
dc.contributor.coauthorAliyeva, Nargiz
dc.contributor.coauthorDundar, Nihal Olgac
dc.contributor.coauthorGencpinar, Pinar
dc.contributor.coauthorGurkas, Esra
dc.contributor.coauthorYilmaz, Sanem Keskin
dc.contributor.coauthorKanmaz, Seda
dc.contributor.coauthorTekgtil, Hasan
dc.contributor.coauthorAksoy, Ayse
dc.contributor.coauthorTuncer, Gokcen Oz
dc.contributor.coauthorArslan, Elif Acar
dc.contributor.coauthorTosun, Ayse
dc.contributor.coauthorAyanoglu, Muge
dc.contributor.coauthorBodur, Muhittin
dc.contributor.coauthorUnay, Bulent
dc.contributor.coauthorKurul, Semra Hiz
dc.contributor.coauthorYis, Uluc
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKızılırmak, Ali Burak
dc.contributor.kuauthorVural, Atay
dc.contributor.kuauthorYousefi, Mohammadreza
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:41:06Z
dc.date.issued2023
dc.description.abstractBackground: To evaluate the clinical features, demographic features, and treatment modalities of pediatric-onset chronic inflammatory demyelinating polyneuropathy (CIDP) in Turkey. Methods: The clinical data of patients between January 2010 and December 2021 were reviewed retrospectively. The patients were evaluated according to the Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society Guideline on the management of CIDP (2021). In addition, patients with typical CIDP were divided into two groups according to the first-line treatment modalities (group 1: IVIg only, group 2: IVIg + steroid). The patients were further divided into two separate groups based on their magnetic resonance imaging (MRI) characteristics. Results: A total of 43 patients, 22 (51.2%) males and 21 (48.8%) females, were included in the study. There was a significant difference between pretreatment and post-treatment modified Rankin scale (mRS) scores (P < 0.05) of all patients. First-line treatments include intravenous immunoglobulin (IVIg) (n = 19, 4 4.2%), IVIg + steroids (n = 20, 46.5%), steroids (n = 1, 2.3%), IVIg + steroids + plasmapheresis (n = 1, 2.3%), and IVIg + plasmapheresis (n = 1, 2.3%). Alternative agent therapy consisted of azathioprine (n = 5), rituximab (n = 1), and azathioprine + mycophenolate mofetil + methotrexate (n = 1). There was no difference between the pretreatment and post-treatment mRS scores of groups 1 and 2 (P > 0.05); however, a significant decrease was found in the mRS scores of both groups with treatment (P < 0.05). The patients with abnormal MRI had significantly higher pretreatment mRS scores compared with the group with normal MRI (P < 0.05). Conclusions: This multicenter study demonstrated that first-line immunotherapy modalities (IVIg vs IVIg + steroids) had equal efficacy for the treatment of patients with CIDP. We also determined that MRI features might be associated with profound clinical features, but did not affect treatment response.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipFunding: This study was funded by The Scientific and Technological Research Council of Turkey, Grant No.: 118S397.
dc.description.volume145
dc.identifier.doi10.1016/j.pediatrneurol.2023.04.018
dc.identifier.eissn1873-5150
dc.identifier.issn0887-8994
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85160102986
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2023.04.018
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23529
dc.identifier.wos1026994200001
dc.keywordsChronic inflammatory demyelinating
dc.keywordsPolyneuropathy
dc.keywordsChildhood
dc.keywordsImmunotherapy
dc.keywordsIVIg
dc.keywordsSteroids
dc.keywordsNeurofascin antibodies
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.grantnoScientific and Technological Research Council of Turkey [118S397]
dc.relation.ispartofPediatric Neurology
dc.subjectClinical neurology
dc.subjectPediatrics
dc.titlePediatric-onset chronic inflammatory demyelinating polyneuropathy: a multicenter study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorVural, Atay
local.contributor.kuauthorYousefi, Mohammadreza
local.contributor.kuauthorKızılırmak, Ali Burak
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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