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3D printed poly(lactic acid) scaffolds modified with chitosan and hydroxyapatite for bone repair applications

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dc.contributor.coauthorN/A
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.kuauthorKavaklı, İbrahim Halil
dc.contributor.kuauthorNazeer, Muhammad Anwaar
dc.contributor.kuauthorÖnder, Özgün Can
dc.contributor.kuauthorSevgili, İlkem
dc.contributor.kuauthorYılgör, Emel
dc.contributor.kuauthorYılgör, İskender
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T23:11:09Z
dc.date.issued2020
dc.description.abstract3D printed poly(lactic acid) (PLA) scaffolds surface modified with chitosan (CS) and hydroxyapatite (HA) to produce a novel bioactive composite scaffold is reported. Excellent mechanical properties of PLA, the bioactivity of CS, and osteogenic characteristics of HA are combined to fabricate composite scaffolds using a simple desktop 3D printer. Scaffolds were characterized through attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) and water contact angle measurements before and after modification. Formic acid was used as a solvent to prepare stable CS/HA dispersions and was found to be a suitable solvent for producing PLA/CS/HA composites. Surface properties of modified scaffolds were superior in terms of hydrophilicity and bioactivity, which resulted in enhanced attachment and proliferation of human osteosarcoma cells in vitro compared to the unmodified PLA scaffolds.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume25
dc.identifier.doi10.1016/j.mtcomm.2020.101515
dc.identifier.eissn2352-4928
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85089495372
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2020.101515
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9574
dc.identifier.wos600997900014
dc.keywordsChitosan
dc.keywordsPLA
dc.keywordsHydroxyapatite
dc.keywords3D printing
dc.keywordsBioactive composite scaffolds
dc.keywordsBone tissue engineering
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofMaterials Today Communications
dc.subjectMaterials science
dc.title3D printed poly(lactic acid) scaffolds modified with chitosan and hydroxyapatite for bone repair applications
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorNazeer, Muhammad Anwaar
local.contributor.kuauthorÖnder, Özgün Can
local.contributor.kuauthorSevgili, İlkem
local.contributor.kuauthorYılgör, Emel
local.contributor.kuauthorKavaklı, İbrahim Halil
local.contributor.kuauthorYılgör, İskender
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Sciences
local.publication.orgunit1College of Engineering
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Chemistry
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2KUYTAM (Koç University Surface Science and Technology Center)
local.publication.orgunit2Graduate School of Sciences and Engineering
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