Publication:
The genetic variants of interferon regulatory factor-3 in children with asthma

dc.contributor.coauthorMosayyebi, Solmaz
dc.contributor.coauthorSaraç, Başak Ezgi
dc.contributor.coauthorBilgiç, Hayriye Akel
dc.contributor.coauthorŞahiner, Umit Murat
dc.contributor.coauthorKalaycı, Ömer
dc.contributor.coauthorKaraaslan, Çağatay
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSaçkesen, Cansın
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:10:35Z
dc.date.issued2020
dc.description.abstractInterferon Regulatory Factor-3 (IRF-3) is one of the key players in the inflammatory response mediated by the innate immune system. Although many studies have implicated a role for IRF-3 in the pathogenesis of inflammatory airway diseases, information about the possible association of IRF-3 genetic variants with asthma is scarce. We aimed to investigate the potential effects of IRF-3 polymorphisms in childhood asthma and asthma-related phenotypes. IRF-3 polymorphisms were first determined by sequencing 25 asthmatic and 25 healthy children. For further analysis, 609 asthmatic children and 191 healthy controls were screened for the genetic variants, such as rs2304204, rs2304205, rs320440, rs34739574, and rs7251. In addition, the relationship between these polymorphisms and asthma-related phenotypic features, including forced expiratory volume in one second values, eosinophil counts, and IgE levels was determined. rs7251 was associated with asthma in the codominant (P = 0.049) and G dominant (P = 0.025) model, however this significance was lost after False Discovery Rate analysis. Other investigated single nucleotide polymorphisms (SNPs) showed no significant association with asthma or asthma-related phenotypes. In conclusion, the seven SNPs of IRF-3 gene are not associated with asthma or asthma-related phenotypes in Turkish asthmatic children.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue12
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipScientific Research Unit of Hacettepe University [012DO6601002] This work was supported by the Scientific Research Unit of Hacettepe University (012DO6601002).
dc.description.volume40
dc.identifier.doi10.1089/jir.2020.0172
dc.identifier.eissn1557-7465
dc.identifier.issn1079-9907
dc.identifier.scopus2-s2.0-85098175526
dc.identifier.urihttps://doi.org/10.1089/jir.2020.0172
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9494
dc.identifier.wos599830300004
dc.keywordsInterferon regulatory factor-3
dc.keywordsAsthma
dc.keywordsSingle nucleotide polymorphisms
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofJournal of Interferon and Cytokine Research
dc.subjectBiochemistry
dc.subjectMolecular biology
dc.subjectCell biology
dc.subjectImmunology
dc.titleThe genetic variants of interferon regulatory factor-3 in children with asthma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSaçkesen, Cansın
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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